Head and neck tumors angiogenesis imaging with 68Ga-NODAGA-RGD in comparison to 18F-FDG PET/CT: a pilot study

被引：20
作者：
Durante, Steve [1 ,2 ,3 ]
Dunet, Vincent [1 ,2 ]
Gorostidi, Francois [2 ,4 ]
Mitsakis, Periklis [1 ,2 ]
Schaefer, Niklaus [1 ,2 ]
Delage, Judith [5 ]
Prior, John O. [2 ,3 ]
机构：
[1] Lausanne Univ Hosp, Dept Diagnost & Intervent Radiol, Rue Bugnon 46, Lausanne, Switzerland
[2] Univ Lausanne, Rue Bugnon 46, Lausanne, Switzerland
[3] Lausanne Univ Hosp, Dept Nucl Med & Mol Imaging, Lausanne, Switzerland
[4] Lausanne Univ Hosp, Dept Otolaryngol Head & Neck Surg, Lausanne, Switzerland
[5] Lausanne Univ Hosp, Dept Pharm, Unit Radiopharm, Lausanne, Switzerland
来源：
EJNMMI RESEARCH | 2020年 / 10卷 / 01期
关键词：
Head and neck cancer; PET; F-18-FDG; Ga-68-NODAGA-RGD; Angiogenesis; EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY; INTEGRIN ALPHA(V)BETA(3) EXPRESSION; SQUAMOUS-CELL CARCINOMA; OROPHARYNGEAL CANCER; CONCURRENT CHEMORADIOTHERAPY; HUMAN-PAPILLOMAVIRUS; F-18-GALACTO-RGD; BIODISTRIBUTION; IN-111-RGD(2); THERAPY;
D O I：
10.1186/s13550-020-00638-w
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Background Angiogenesis plays an important role in head and neck squamous cell carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution of Ga-68-NODAGA-RGD PET/CT for imaging alpha(v)beta(3) integrins involved in tumor angiogenesis to F-18-FDG PET/CT in patients with HNSCC. Material and methods Ten patients (aged 58.4 +/- 8.3 years [range, 44-73 years], 6 males, 4 females) with a total of 11 HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) from both Ga-68-NODAGA-RGD and F-18-FDG PET/CT scans were recorded for primary tumor and compared with the Wilcoxon signed-rank test. The relation between the SUV of both tracers was assessed using the Spearman correlation. Results All HNSCC tumors were visible with both tracers. Quantitative analysis showed higher F-18-FDG SUVmax in comparison to Ga-68-NODAGA-RGD (14.0 +/- 6.1 versus 3.9 +/- 1.1 g/mL, p = 0.0017) and SUVmean (8.2 +/- 3.1 versus 2.0 +/- 0.8 g/mL, p = 0.0017). Both F-18-FDG and Ga-68-NODAGA-RGD uptakes were neither correlated with grade, HPV status nor p16 protein expression (p >= 0.17). Conclusion All HNSCC tumors were detected with both tracers with higher uptake with F-18-FDG, however. Ga-68-NODAGA-RGD has a different spatial distribution than F-18-FDG bringing different tumor information.
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页数：11
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