A STUDY ON CORRELATION BETWEEN CONTRAST-ENHANCED ULTRASOUND PARAMETERS AND PATHOLOGICAL FEATURES OF DIABETIC NEPHROPATHY

被引：4
作者：
Wang, Yiru [1 ,2 ]
Zhao, Ping [1 ,2 ]
Li, Nan [1 ]
Dong, Zheyi [3 ,4 ]
Lin, Lin [1 ]
Liu, Jiaona [3 ,4 ]
Liang, Shiyuan [1 ]
Wang, Qian [3 ,4 ]
Tang, Jie [1 ,2 ]
Luo, Yukun [1 ,2 ,4 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Ultrasound, Med Ctr 1, 28 Fuxing Rd, Beijing 100853, Peoples R China
[2] Chinese PLA, Sch Med, Beijing, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Chinese PLA Inst Nephrol, Beijing Key Lab Kidney Dis, Dept Nephrol,Med Ctr 1, Beijing, Peoples R China
[4] Natl Clin Res Ctr Kidney Dis, State Key Lab Kidney Dis, Beijing, Peoples R China
来源：
ULTRASOUND IN MEDICINE AND BIOLOGY | 2022年 / 48卷 / 02期
关键词：
Diabetic nephropathy; Renal pathology; Renal microperfusion; Glomerulosclerosis rate; Contrast-enhanced ultrasound; RENAL PERFUSION; MICROCIRCULATION;
D O I：
10.1016/j.ultrasmedbio.2021.08.014
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
The objective of this study was to evaluate the correlation between contrast-enhanced ultrasound (CEUS) parameters and histopathological features in patients with diabetic nephropathy (DN). Sixty-two patients with DN (44 men, mean age: 52.61 +/- 10.63 y) were enrolled. They underwent renal biopsy for DN at the Department of Ultrasound, PLA Hospital, between May 2017 and February 2020. Renal tissue was obtained by ultrasound-guided percutaneous needle biopsy. CEUS was performed, and time-intensity curves (TICs) and renal perfusion parameters were analyzed. Differences in CEUS parameters were analyzed according to the glomerular classification and interstitial fibrosis-tubular atrophy (IFTA) score. Continuous variables were evaluated using the analysis of variance or Mann-Whitney U-test. Discontinuous variables were compared with the chi(2)-test. Spearman correlation analyses evaluated associations among quantitative ultrasound perfusion parameters and histopathological characteristics. Peak enhancement (PE), wash-in rate (WiR), wash-in perfusion index (WiP1) and wash-out rate (VVoR) of the cortex, and their cortex/medulla ratios, decreased with increasing glomerular classification grade (p < 0.05). The fall time (FT) of the cortex, and their cortex/medulla ratios, increased with increasing glomerular classification grade (p < 0.05). There were no significant differences in the CEUS parameters for different IFTA scores. The perfusion volume-relevant parameters (such as PE, WiR and WiP1) had a negative correlation (p < 0.05), while the perfusion time-relevant parameters (such as RT and FT) had a positive correlation (p < 0.05), with the severity of glomerular lesions, glomerulosclerosis rate and number of Kimmelstiel-Wilson lesions. The CEUS parameters of the cortex could reflect pathological characteristics, espe- cially changes in glomerular lesions. (C) 2021 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.
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页码：228 / 236
页数：9
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