Mitochondria are considered to play an important role in oxidative stress response since they are a source of reactive oxygen species and are also targeted by these species. This study examined the mitochondrial conditions in cells of epithelial origin that were exposed to H(2)O(2) and found a decline in the membrane potential along with a specific loss of UQCRC1, a sub-unit of complex III, suggesting that mitochondrial dysfunction occurs upon exposure to oxidative stress. This observation led to the hypothesis that certain cellular responses to oxidative stress occurred because of mitochondrial dysfunction. When mitochondria-less (pseudo rho 0) cells were examined as a model of mitochondrial dysfunction, striking similarities were found in their cellular responses compared with those found in cells exposed to oxidative stress, including changes in gene expression and gelatinolytic enzyme activities, thus suggesting that cellular responses to oxidative stress were partly mediated by mitochondrial dysfunction. This possibility was further validated by microarray analysis, which suggested that almost one-fourth of the cellular responses to oxidative stress were mediated by mitochondrial dysfunction that accompanies oxidative stress, thereby warranting a therapeutic strategy that targets mitochondria for the treatment of oxidative stress-associated diseases.
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Ishikawa, Fumihiro
;
Nose, Kiyoshi
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Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Nose, Kiyoshi
;
Shibanuma, Motoko
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Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
机构:
Ind Toxicol Res Ctr, Herbal Res Sect, Lucknow 226001, Uttar Pradesh, IndiaInd Toxicol Res Ctr, Herbal Res Sect, Lucknow 226001, Uttar Pradesh, India
Kakkar, Poonam
;
Singh, B. K.
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Ind Toxicol Res Ctr, Herbal Res Sect, Lucknow 226001, Uttar Pradesh, IndiaInd Toxicol Res Ctr, Herbal Res Sect, Lucknow 226001, Uttar Pradesh, India
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Kanome, T.
;
Itoh, N.
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Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Itoh, N.
;
Ishikawa, F.
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h-index: 0
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Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Ishikawa, F.
;
Mori, K.
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Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Mori, K.
;
Kim-Kaneyama, J-R
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Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Kim-Kaneyama, J-R
;
Nose, K.
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机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Nose, K.
;
Shibanuma, M.
论文数: 0引用数: 0
h-index: 0
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Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Ishikawa, Fumihiro
;
Nose, Kiyoshi
论文数: 0引用数: 0
h-index: 0
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Nose, Kiyoshi
;
Shibanuma, Motoko
论文数: 0引用数: 0
h-index: 0
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
机构:
Ind Toxicol Res Ctr, Herbal Res Sect, Lucknow 226001, Uttar Pradesh, IndiaInd Toxicol Res Ctr, Herbal Res Sect, Lucknow 226001, Uttar Pradesh, India
Kakkar, Poonam
;
Singh, B. K.
论文数: 0引用数: 0
h-index: 0
机构:
Ind Toxicol Res Ctr, Herbal Res Sect, Lucknow 226001, Uttar Pradesh, IndiaInd Toxicol Res Ctr, Herbal Res Sect, Lucknow 226001, Uttar Pradesh, India
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Kanome, T.
;
Itoh, N.
论文数: 0引用数: 0
h-index: 0
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Itoh, N.
;
Ishikawa, F.
论文数: 0引用数: 0
h-index: 0
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Ishikawa, F.
;
Mori, K.
论文数: 0引用数: 0
h-index: 0
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Mori, K.
;
Kim-Kaneyama, J-R
论文数: 0引用数: 0
h-index: 0
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Kim-Kaneyama, J-R
;
Nose, K.
论文数: 0引用数: 0
h-index: 0
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan
Nose, K.
;
Shibanuma, M.
论文数: 0引用数: 0
h-index: 0
机构:
Showa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, JapanShowa Univ, Sch Pharmaceut Sci, Dept Microbiol, Shinagawa Ku, Tokyo 1428555, Japan