共 108 条
The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis
被引:161
作者:

Maher, Pamela
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Salk Inst Biol Studies, Cellular Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies, Cellular Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

van Leyen, Klaus
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Harvard Med Sch, Cambridge, MA USA Salk Inst Biol Studies, Cellular Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

Dey, Partha Narayan
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机构:
Univ Med Ctr, Mainz, Germany
Johannes Gutenberg Univ Mainz, Focus Program Translat Neurosci FTN, Dept Neurol, Mainz, Germany Salk Inst Biol Studies, Cellular Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

Honrath, Birgit
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机构:
Univ Groningen, Dept Mol Pharmacol, Groningen, Netherlands Salk Inst Biol Studies, Cellular Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

Dolga, Amalia
论文数: 0 引用数: 0
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机构:
Univ Groningen, Dept Mol Pharmacol, Groningen, Netherlands Salk Inst Biol Studies, Cellular Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

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机构:
[1] Salk Inst Biol Studies, Cellular Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
[2] Harvard Med Sch, Cambridge, MA USA
[3] Univ Med Ctr, Mainz, Germany
[4] Johannes Gutenberg Univ Mainz, Focus Program Translat Neurosci FTN, Dept Neurol, Mainz, Germany
[5] Univ Groningen, Dept Mol Pharmacol, Groningen, Netherlands
来源:
基金:
美国国家卫生研究院;
关键词:
Calcium;
Oxytosis;
Ferroptosis;
Oxidative stress;
SOCE;
APOPTOSIS-INDUCING FACTOR;
TRANSIENT FOCAL ISCHEMIA;
CEREBRAL-ISCHEMIA;
NEURONAL CELLS;
NERVOUS-SYSTEM;
CALCIUM-IONS;
GLUTATHIONE DEPLETION;
ENDOPLASMIC-RETICULUM;
SUPEROXIDE-DISMUTASE;
HIPPOCAMPAL-NEURONS;
D O I:
10.1016/j.ceca.2017.05.007
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Ca2+ ions play a fundamental role in cell death mediated by oxidative glutamate toxicity or oxytosis, a form of programmed cell death similar and possibly identical to other forms of cell death like ferroptosis. Ca2+ influx from the extracellular space occurs late in a cascade characterized by depletion of the intracellular antioxidant glutathione, increases in cytosolic reactive oxygen species and mitochondrial dysfunction. Here, we aim to compare oxidative glutamate toxicity with ferroptosis, address the signaling pathways that culminate in Ca2+ influx and cell death and discuss the proteins that mediate this. Recent evidence hints toward a role of the machinery responsible for store-operated Ca2+ entry (SOCE), which refills the endoplasmic reticulum (ER) after receptor-mediated ER Ca2+ release or other forms of store depletion. Pharmacological inhibition of SOCE or transcriptional downregulation of proteins involved in SOCE like the ER Ca2+ sensor STIM1, the plasma membrane C2+ channels Orai1 and TRPC1 and the linking protein Homer protects against oxidative glutamate toxicity and direct oxidative stress caused by hydrogen peroxide or 1-methyl-4-phenylpyridinium (MPP+) injury, a cellular model of Parkinson's disease. This suggests that SOCE inhibition might have some potential therapeutic effects in human disease associated with oxidative stress like neurodegenerative disorders. (C) 2017 Elsevier Ltd. All rights reserved.
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页码:47 / 55
页数:9
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