Loaded and in vitro Drug Release of Anticancer Drugs in Porous Metal-Organic Frameworks

被引：8

作者：

Yang Bao-Chun ^{[1
]}

Jiang Yao-Dong ^{[2
]}

Qin Xue-Juan ^{[1
]}

Chen Zhi-Liang ^{[1
]}

Ren Fei ^{[1
]}

机构：

[1] So Med Univ, Dept Pharm, Guangzhou 510515, Guangdong, Peoples R China

[2] So Med Univ, Nanfang Hosp, Dept Urol, Guangzhou 510515, Guangdong, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2012年 / 33卷 / 01期

关键词：

Metal-organic framework(MOF); Capsaicin; 5-Fluouourail(5-FU); Drug loading rate; Drug sustained release; Cytotoxicity;

D O I：

10.3969/j.issn.0251-0790.2012.01.004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Porous metal-organic frameworks(MOF-5) were synthesized and the structure of synthetic MOF-5 was confirmed by XRD and IR spectrum. According to the result of TG, the synthetic MOF-5 displayed better thermo-stabilization. The capsaicin or 5-fluouourail was loaded in synthetic MOF-5 and in vitro drug release profile were investigated, respectively. The highest drug loading rates are 0. 592 g/g MOF for capsaicin and 0. 315 g/g MOF for 5-FU in drug-loaded MOF-5, respectively. The in vitro drug release profile of both MOF-5 formulations showed a clear biphasic release pattern. Cytotoxicity test showed that MOF-5 displayed good bio-compatility.

引用

页码：26 / 31

页数：6

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