Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development

被引：233
作者：
Papaccio, Federica [1 ]
Paino, Francesca [2 ]
Regad, Tarik [3 ,4 ]
Papaccio, Gianpaolo [2 ]
Desiderio, Vincenzo [2 ]
Tirino, Virginia [2 ]
机构：
[1] Univ Campania L Vanvitelli, Dipartimento Med Chirurg Internist Clin Speriment, Naples, Italy
[2] Univ Campania L Vanvitelli, Dipartimento Med Sperimentale, Sez Sez Biotecnol Istol Med & Biol Mol, Naples, Italy
[3] Univ Campania L Vanvitelli, Dipartimento Biochim Biofis & Patol Gen, Naples, Italy
[4] Nottingham Trent Univ, Sch Sci & Technol, John van Geest Canc Res Ctr, Nottingham, England
来源：
STEM CELLS TRANSLATIONAL MEDICINE | 2017年 / 6卷 / 12期
关键词：
Mesenchymal stem cells; Cancer progression; Microenvironment; Epithelial to mesenchymal transition; Drug resistance; HUMAN BONE-MARROW; STROMAL CELLS; IN-VITRO; REGENERATIVE THERAPY; TUMOR PROGRESSION; INITIATING CELLS; SOLID TUMORS; PROMOTE; DIFFERENTIATION; GROWTH;
D O I：
10.1002/sctm.17-0138
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Tumors are composed of different types of cancer cells that contribute to tumor heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an important role in cancer initiation and progression. Like their stem cells counterpart, CSCs are also characterized by self-renewal and the capacity to differentiate. A particular population of CSCs is constituted by mesenchymal stem cells (MSCs) that differentiate into cells of mesodermal characteristics. Several studies have reported the potential pro-or anti-tumorigenic influence of MSCs on tumor initiation and progression. In fact, MSCs are recruited to the site of wound healing to repair damaged tissues, an event that is also associated with tumorigenesis. In other cases, resident or migrating MSCs can favor tumor angiogenesis and increase tumor aggressiveness. This interplay between MSCs and cancer cells is fundamental for cancerogenesis, progression, and metastasis. Therefore, an interesting topic is the relationship between cancer cells, CSCs, and MSCs, since contrasting reports about their respective influences have been reported. In this review, we discuss recent findings related to conflicting results on the influence of normal and CSCs in cancer development. The understanding of the role of MSCs in cancer is also important in cancer management.
引用
收藏
页码：2115 / 2125
页数：11
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