9-Azanoradamantane N-Oxyl (Nor-AZADO): A Highly Active Organocatalyst for Alcohol Oxidation

被引：68

作者：

Hayashi, Masaki ^{[1
,2
]}

Sasano, Yusuke ^{[1
]}

Nagasawa, Shota ^{[1
]}

Shibuya, Masatoshi ^{[1
]}

Iwabuchi, Yoshiharu ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Organ Chem, Sendai, Miyagi 9808578, Japan

[2] Daiichi Sankyo Co Ltd, Proc Technol Res Labs, Hiratsuka, Kanagawa 2540014, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 12期

基金：

日本学术振兴会;

关键词：

organocatalyst; nitroxyl radical; alcohol oxidation; aerobic oxidation; 2-azaadamantane N-oxyl AZADO; TERTIARY ALLYLIC ALCOHOLS; AEROBIC OXIDATION; SELECTIVE OXIDATION; EFFICIENT; ALDEHYDES; TEMPO; KETONES; REARRANGEMENT; NITRITE; SYSTEM;

D O I：

10.1248/cpb.59.1570

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A highly active organocatalyst for alcohol oxidation has been developed. 9-Azanoradamantane N-oxyl (Nor-AZADO 4), constituting an unhindered, stable nitroxyl radical, exhibits superior catalytic activity to 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and AZADOs in the oxidation of alcohols to their corresponding carbonyl compounds.

引用

页码：1570 / 1573

页数：4

共 31 条

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