Biscinchona alkaloids as highly efficient bifunctional organocatalysts for the asymmetric conjugate addition of malonates to nitroalkenes at ambient temperature

被引：27

作者：

Li, Fei ^{[1
]}

Li, Ying-Zi ^{[1
]}

Jia, Zhen-Shan ^{[1
]}

Xu, Ming-Hua ^{[2
]}

Tian, Ping ^{[1
]}

Lin, Guo-Qiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, CAS Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

TETRAHEDRON | 2011年 / 67卷 / 52期

关键词：

Bifinctional; Biscinchona alkaloids; Nitroalkenes; Conjugate addition; Baclofen; BAYLIS-HILLMAN REACTION; ENANTIOSELECTIVE MICHAEL ADDITION; 1,3-DICARBONYL COMPOUNDS; CINCHONA ALKALOIDS; QUATERNARY STEREOCENTERS; TERTIARY STEREOCENTERS; ADJACENT QUATERNARY; ORGANIC CATALYST; HENRY REACTION; CHIRAL AMINES;

D O I：

10.1016/j.tet.2011.08.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel bifunctional bisalkaloids have been developed as highly efficient catalysts for the asymmetric conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes with low catalyst loading (1 mol %) at ambient temperature, providing the products with excellent enantioselectivities (up to 97% ee). Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

引用

页码：10186 / 10194

页数：9

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