Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version QuantiFERON-TB Gold IT

被引：59

作者：

Hoffmann, H. ^{[1
,2
]}

Avsar, K. ^{[3
]}

Goeres, R. ^{[3
]}

Mavi, S. -C. ^{[3
]}

Hofmann-Thiel, S. ^{[1
,2
]}

机构：

[1] Zweigniederlassung Synlab MVZ Augsburg GmbH, Synlab MVZ Gauting, Gauting, Germany

[2] IML Red GmbH, Inst Microbiol & Lab Med, WHO Supranatl Reference Lab TB, Gauting, Germany

[3] Asklepios Fachkliniken Munchen Gauting, Dept Infect Dis, Gauting, Germany

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2016年 / 22卷 / 08期

关键词：

Interferon-gamma release assay; QuantiFERON-TB Gold in tube; QuantiFERON-TB Gold plus; Sensitivity; Tuberculosis; GAMMA RELEASE ASSAYS; TUBERCULOSIS INFECTION; ACTIVE TUBERCULOSIS; DIAGNOSIS; METAANALYSIS;

D O I：

10.1016/j.cmi.2016.05.006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

QuantiFERON-TB Gold IT analyses interferon-gamma release from CD4(+) T cells after stimulation with specific tuberculosis (TB) antigens. Its sensitivity is approximately 80% for active TB. A new test generation (QFTGplus) also analyses the response of CD8(+) T cells. We investigated both test generations in a direct head-to-head comparison in a German pulmonary hospital. Sensitivity rates for active TB were identical, no matter whether diagnosis was bacteriologically confirmed or not. H. Hoffmann, (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：701 / 703

页数：3

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