The pharmacotherapy of psychotic disturbances is not limited on neuroleptics, but includes Clomethiazol and Benzodiazepines (e.g. to treat delirium) or antidepressants (e.g. to treat psychotic depression) too. Even more divergent is the psychosocial treatment of different psychotic states. In this overview the diagnostic principles, needed for a differential therapy of psychotic disorders, are described.