Atenolol reduces salivary activity in pups of spontaneously hypertensive and normotensive rats treated during pregnancy and lactation

被引：7

作者：

Elias, Gracieli P. ^{[2
]}

Sassaki, Kikue T. ^{[1
]}

Delbem, Alberto C. B. ^{[3
]}

Antoniali, Cristina ^{[1
]}

机构：

[1] Univ Nacl Estadual Sao Paulo, Sch Dent & Aracatuba, Dept Basic Sci, Sao Paulo, Brazil

[2] Univ Nacl Estadual Sao Paulo, Sch Dent Aracatuba, Pediat Dent Postgrad Program, Sao Paulo, Brazil

[3] Univ Nacl Estadual Sao Paulo, Sch Dent Aracatuba, Dept Pediat Dent, Sao Paulo, Brazil

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2008年 / 30卷 / 02期

关键词：

atenolol; salivary glands; spontaneously hypertensive rats (SHR);

D O I：

10.1080/10641960801931923

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The salivary activity in pups of spontaneously hypertensive rats (SHR) and Wistar (W) rats treated with atenolol during pregnancy, and lactation was evaluated. Atenolol's anti-hypertensive effect on the SHR rats was noticed from the beginning of treatment. Atenolol-treated SHR and Wistar rat pups showed a decrease in salivary gland weight, salivary flow, and protein concentration, with no alteration in salivary amylase activity. Atenolol's effect on salivary glands can interfere with oral health maintenance.

引用

页码：133 / 141

页数：9

共 34 条

[1]

[Anonymous], CARIE DENTARIA DOENC

[2] Relationships between medication intake, complaints of dry mouth, salivary flow rate and composition, and the rate of tooth demineralization in situ [J].

Bardow, A ;

Nyvad, B ;

Nauntofte, B .

ARCHIVES OF ORAL BIOLOGY, 2001, 46 (05) :413-423

[3] Management of mild preeclampsia [J].

Barton, JR ;

Witlin, AG ;

Sibai, BM .

CLINICAL OBSTETRICS AND GYNECOLOGY, 1999, 42 (03) :455-469

[4] NEUROTRANSMITTER CONTROL OF SECRETION [J].

BAUM, BJ .

JOURNAL OF DENTAL RESEARCH, 1987, 66 :628-632

[5] Blockade of isoprenaline-induced fluid and protein secretion by the mandibular glands of the red kangaroo, Macropus rufus, with selective antagonists [J].

Beal, AM .

ARCHIVES OF ORAL BIOLOGY, 2000, 45 (08) :701-706

[6]

BERNARDE MA, 1956, J DENT RES, V35, P326

[7] Management of hypertension in pregnancy [J].

Chung N.A.Y. ;

Beevers D.G. ;

Lip G.Y.H. .

American Journal of Cardiovascular Drugs, 2001, 1 (4) :253-262

[8] The impact of saliva on patient care: A literature review [J].

Diaz-Arnold, AM ;

Marek, CA .

JOURNAL OF PROSTHETIC DENTISTRY, 2002, 88 (03) :337-343

[9] Treatment of hypertension in pregnancy: Effect of atenolol on maternal disease, preterm delivery, and fetal growth [J].

Easterling, TR ;

Carr, DB ;

Brateng, D ;

Diederichs, C ;

Schmucker, B .

OBSTETRICS AND GYNECOLOGY, 2001, 98 (03) :427-433

[10]

Elias Gracieli Prado, 2006, J. Appl. Oral Sci., V14, P253, DOI 10.1590/S1678-77572006000400008

← 1 2 3 4 →