Sleep Control, GPCRs, and Glucose Metabolism

被引：28
作者：
Tsuneki, Hiroshi [1 ]
Sasaoka, Toshiyasu [1 ]
Sakurai, Takeshi [2 ]
机构：
[1] Toyama Univ, Dept Clin Pharmacol, 2630 Sugitani, Toyama 9300194, Japan
[2] Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, Tsukuba, Ibaraki 3058575, Japan
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2016年 / 27卷 / 09期
关键词：
DIET-INDUCED OBESITY; SPONTANEOUSLY HYPERTENSIVE-RATS; OREXIN RECEPTOR ANTAGONISTS; FUKUOKA DIABETES REGISTRY; EYE-MOVEMENT SLEEP; INSULIN-RESISTANCE; BETA-CELLS; SLEEP/WAKEFULNESS STATES; PERIPHERAL-TISSUES; DAYTIME SLEEPINESS;
D O I：
10.1016/j.tem.2016.06.011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Modern lifestyles prolong daily activities into the nighttime, disrupting circadian rhythms, which may cause sleep disturbances. Sleep disturbances have been implicated in the dysregulation of blood glucose levels and reported to increase the risk of type 2 diabetes (T2D) and diabetic complications. Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including gamma-aminobutyric acid (GABA) agonists, melatonin agonists, and orexin receptor antagonists. A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. In this review we focus on the beneficial impact of sleep on glucose metabolism and suggest a possible strategy for therapeutic intervention against sleep-related metabolic disorders.
引用
收藏
页码：633 / 642
页数：10
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