Sleep Control, GPCRs, and Glucose Metabolism

被引：28
作者：
Tsuneki, Hiroshi [1 ]
Sasaoka, Toshiyasu [1 ]
Sakurai, Takeshi [2 ]
机构：
[1] Toyama Univ, Dept Clin Pharmacol, 2630 Sugitani, Toyama 9300194, Japan
[2] Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, Tsukuba, Ibaraki 3058575, Japan
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2016年 / 27卷 / 09期
关键词：
DIET-INDUCED OBESITY; SPONTANEOUSLY HYPERTENSIVE-RATS; OREXIN RECEPTOR ANTAGONISTS; FUKUOKA DIABETES REGISTRY; EYE-MOVEMENT SLEEP; INSULIN-RESISTANCE; BETA-CELLS; SLEEP/WAKEFULNESS STATES; PERIPHERAL-TISSUES; DAYTIME SLEEPINESS;
D O I：
10.1016/j.tem.2016.06.011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Modern lifestyles prolong daily activities into the nighttime, disrupting circadian rhythms, which may cause sleep disturbances. Sleep disturbances have been implicated in the dysregulation of blood glucose levels and reported to increase the risk of type 2 diabetes (T2D) and diabetic complications. Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including gamma-aminobutyric acid (GABA) agonists, melatonin agonists, and orexin receptor antagonists. A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. In this review we focus on the beneficial impact of sleep on glucose metabolism and suggest a possible strategy for therapeutic intervention against sleep-related metabolic disorders.
引用
收藏
页码：633 / 642
页数：10
相关论文
共 116 条
  • [1] Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats
    Agil, Ahmad
    Rosado, Isaac
    Ruiz, Rosario
    Figueroa, Adriana
    Zen, Nourahouda
    Fernandez-Vazquez, Gumersindo
    [J]. JOURNAL OF PINEAL RESEARCH, 2012, 52 (02) : 203 - 210
  • [2] Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks
    Albrecht, Urs
    [J]. NEURON, 2012, 74 (02) : 246 - 260
  • [3] Circadian Timing of Food Intake Contributes to Weight Gain
    Arble, Deanna M.
    Bass, Joseph
    Laposky, Aaron D.
    Vitaterna, Martha H.
    Turek, Fred W.
    [J]. OBESITY, 2009, 17 (11) : 2100 - 2102
  • [4] Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
    Bonnefond, Amelie
    Clement, Nathalie
    Fawcett, Katherine
    Yengo, Loic
    Vaillant, Emmanuel
    Guillaume, Jean-Luc
    Dechaume, Aurelie
    Payne, Felicity
    Roussel, Ronan
    Czernichow, Sebastien
    Hercberg, Serge
    Hadjadj, Samy
    Balkau, Beverley
    Marre, Michel
    Lantieri, Olivier
    Langenberg, Claudia
    Bouatia-Naji, Nabila
    Charpentier, Guillaume
    Vaxillaire, Martine
    Rocheleau, Ghislain
    Wareham, Nicholas J.
    Sladek, Robert
    McCarthy, Mark I.
    Dina, Christian
    Barroso, Ines
    Jockers, Ralf
    Froguel, Philippe
    [J]. NATURE GENETICS, 2012, 44 (03) : 297 - U98
  • [5] Placebo-Controlled Pilot Study of Ramelteon for Adiposity and Lipids in Patients With Schizophrenia
    Borba, Christina P. C.
    Fan, Xiaoduo
    Copeland, Paul M.
    Paiva, Alexander
    Freudenreich, Oliver
    Henderson, David C.
    [J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2011, 31 (05) : 653 - 658
  • [6] AN IMIDAZOPYRIDINE ANXIOLYTIC ALTERS GLUCOSE-TOLERANCE IN PATIENTS - A PILOT INVESTIGATION
    BOTTAI, T
    CARTAULT, F
    POUGET, R
    BLAYAC, JP
    PETIT, P
    [J]. CLINICAL NEUROPHARMACOLOGY, 1995, 18 (01) : 79 - 82
  • [7] A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    Bouatia-Naji, Nabila
    Bonnefond, Amelie
    Cavalcanti-Proenca, Christine
    Sparso, Thomas
    Holmkvist, Johan
    Marchand, Marion
    Delplanque, Jerome
    Lobbens, Stephane
    Rocheleau, Ghislain
    Durand, Emmanuelle
    De Graeve, Franck
    Chevre, Jean-Claude
    Borch-Johnsen, Knut
    Hartikainen, Anna-Liisa
    Ruokonen, Aimo
    Tichet, Jean
    Marre, Michel
    Weill, Jacques
    Heude, Barbara
    Tauber, Maithe
    Lemaire, Katleen
    Schuit, Frans
    Elliott, Paul
    Jorgensen, Torben
    Charpentier, Guillaume
    Hadjadj, Samy
    Cauchi, Stephane
    Vaxillaire, Martine
    Sladek, Robert
    Visvikis-Siest, Sophie
    Balkau, Beverley
    Levy-Marchal, Claire
    Pattou, Francois
    Meyre, David
    Blakemore, Alexandra I. F.
    Jarvelin, Marjo-Riita
    Walley, Andrew J.
    Hansen, Torben
    Dina, Christian
    Pedersen, Oluf
    Froguel, Philippe
    [J]. NATURE GENETICS, 2009, 41 (01) : 89 - 94
  • [8] Promotion of sleep by targeting the orexin system in rats, dogs and humans
    Brisbare-Roch, Catherine
    Dingemanse, Jasper
    Koberstein, Ralf
    Hoever, Petra
    Aissaoui, Hamed
    Flores, Susan
    Mueller, Celia
    Nayler, Oliver
    van Gerven, Joop
    de Haas, Sanne L.
    Hess, Patrick
    Qiu, Changbin
    Buchmann, Stephan
    Scherz, Michael
    Weller, Thomas
    Fischli, Walter
    Clozel, Martine
    Jenck, Francois
    [J]. NATURE MEDICINE, 2007, 13 (02) : 150 - 155
  • [9] Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction A Randomized, Crossover Study
    Broussard, Josiane L.
    Ehrmann, David A.
    Van Cauter, Eve
    Tasali, Esra
    Brady, Matthew J.
    [J]. ANNALS OF INTERNAL MEDICINE, 2012, 157 (08) : 549 - 557
  • [10] Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption
    Buxton, Orfeu M.
    Cain, Sean W.
    O'Connor, Shawn P.
    Porter, James H.
    Duffy, Jeanne F.
    Wang, Wei
    Czeisler, Charles A.
    Shea, Steven A.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (129)
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