Targeting chromatin in fungal pathogens as a novel therapeutic strategy: histone modification gets infectious

被引：0
作者：
Hnisz, Denes [1 ]
Tscherner, Michael [1 ]
Kuchler, Karl [1 ]
机构：
[1] Med Univ Vienna, Christian Doppler Lab Infect Biol, Max F Perutz Labs, A-1030 Vienna, Austria
来源：
EPIGENOMICS | 2011年 / 3卷 / 02期
关键词：
antifungal drug discovery; chromatin modification; epigenetics; fungal pathogens; immune evasion; pathogenesis; DEACETYLASE INHIBITORS; MECHANISMS; VIRULENCE;
D O I：
10.2217/EPI.11.7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
引用
收藏
页码：129 / 132
页数：4
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  • [1] Novel Inhibitor of Plasmodium Histone Deacetylase That Cures P. berghei-Infected Mice
    Agbor-Enoh, S.
    Seudieu, C.
    Davidson, E.
    Dritschilo, A.
    Jung, M.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (05) : 1727 - 1734
  • [2] The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype
    Cowen, Leah E.
    [J]. NATURE REVIEWS MICROBIOLOGY, 2008, 6 (03) : 187 - 198
  • [3] Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis
    da Rosa, Jessica Lopes
    Boyartchuk, Victor L.
    Zhu, Lihua Julie
    Kaufman, Paul D.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (04) : 1594 - 1599
  • [4] The role of Toll-like receptors and C-type lectins for vaccination against Candida albicans
    Ferwerda, Gerben
    Netea, Mihai G.
    Joosten, Leo A.
    van der Meer, Jos W. M.
    Romani, Luigina
    Kullberg, Bart Jan
    [J]. VACCINE, 2010, 28 (03) : 614 - 622
  • [5] The Set3/Hos2 Histone Deacetylase Complex Attenuates cAMP/PKA Signaling to Regulate Morphogenesis and Virulence of Candida albicans
    Hnisz, Denes
    Majer, Olivia
    Frohner, Ingrid E.
    Komnenovic, Vukoslav
    Kuchler, Karl
    [J]. PLOS PATHOGENS, 2010, 6 (05) : 1 - 18
  • [6] Transcriptional loops meet chromatin: a dual-layer network controls white-opaque switching in Candida albicans
    Hnisz, Denes
    Schwarzmueller, Tobias
    Kuchler, Karl
    [J]. MOLECULAR MICROBIOLOGY, 2009, 74 (01) : 1 - 15
  • [7] Translating the histone code
    Jenuwein, T
    Allis, CD
    [J]. SCIENCE, 2001, 293 (5532) : 1074 - 1080
  • [8] Pneumocystis carinii Expresses an Active Rtt109 Histone Acetyltransferase
    Kottom, Theodore J.
    Han, Junhong
    Zhang, Zhiguo
    Limper, Andrew H.
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2011, 44 (06) : 768 - 776
  • [9] Chromatin modifications and their function
    Kouzarides, Tony
    [J]. CELL, 2007, 128 (04) : 693 - 705
  • [10] Shared epigenetic mechanisms control virulence factors in protozoan parasites
    Lopez-Rubio, Jose Juan
    Riviere, Loic
    Scherf, Artur
    [J]. CURRENT OPINION IN MICROBIOLOGY, 2007, 10 (06) : 560 - 568
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