Allosteric modulation of monomeric proteins

被引：36
作者：
Ascenzi, P
Bocedi, A
Bolli, A
Fasano, M
Notari, S
Polticelli, F
机构：
[1] Univ Roma Tre, Dipartimento Biol, I-00146 Rome, Italy
[2] Univ Roma Tre, Lab Interdipartimentale Microscopia Elettron, I-00146 Rome, Italy
[3] IRCCS Lazzaro Spallanzani, Ist Nazl Malattie Infett, I-00149 Rome, Italy
[4] Univ Insubria, Dipartimento Biol Strutturale & Funz, I-21052 Busto Arsizio, VA, Italy
[5] Univ Insubria, Ctr Neurosci, I-21052 Busto Arsizio, VA, Italy
来源：
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION | 2005年 / 33卷 / 03期
关键词：
allostery; monomeric proteins; myoglobin; albumin; thrombin;
D O I：
10.1002/bmb.2005.494033032470
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Multimeric proteins ( e. g. hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins ( e. g. myoglobin) usually are assumed to be nonallosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors casts doubts on this assumption. Here, the allosteric properties of sperm whale myoglobin, human serum albumin, and human alpha-thrombin, generally considered as molecular models of monomeric proteins, are summarized.
引用
收藏
页码：169 / 176
页数：8
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