AAA+ proteins: diversity in function, similarity in structure

被引：108

作者：

Snider, Jamie ^{[1
]}

Houry, Walid A. ^{[1
]}

机构：

[1] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

ATPase associated with various cellular activities (AAA plus ); p-loop NTPase; remodelling; walker A motif; walker B motif;

D O I：

10.1042/BST0360072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The AAA+ (ATPases associated with various cellular activities) superfamily of proteins represents a distinct lineage of the larger class of P-loop NTPases. Members of this superfamily use the power of nuclecitide binding and hydrolysis to direct molecular remodelling events. All AAA+ proteins share a common core architecture, which, through various sequence and structural modifications, has been adapted for use in a remarkably diverse range of functions. The following mini-review provides a concise description of the major structural elements common to all AAA+ proteins in the context of their mechanistic roles. in addition, the evolutionary and functional diversity of this superfamily is described on the basis of recent classification studies.

引用

页码：72 / 77

页数：6

共 42 条

[11] VIRAL-PROTEINS CONTAINING THE PURINE NTP-BINDING SEQUENCE PATTERN [J].

GORBALENYA, AE ;

KOONIN, EV .

NUCLEIC ACIDS RESEARCH, 1989, 17 (21) :8413-8440

[12] Proteolysis in bacterial regulatory circuits [J].

Gottesman, S .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2003, 19 :565-587

[13] Crystal structure of the delta' subunit of the cramp-loader complex of E-coli DNA polymerase III [J].

Guenther, B ;

Onrust, R ;

Sali, A ;

ODonnell, M ;

Kuriyan, J .

CELL, 1997, 91 (03) :335-345

[14] Evolutionary history and higher order classification of AAA plus ATPases [J].

Iyer, LM ;

Leipe, DD ;

Koonin, EV ;

Aravind, L .

JOURNAL OF STRUCTURAL BIOLOGY, 2004, 146 (1-2) :11-31

[15] Ordered ATP hydrolysis in the γ complex clamp loader AAA plus machine [J].

Johnson, A ;

O'Donnell, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (16) :14406-14413

[16] TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a [J].

Kanemaki, M ;

Kurokawa, Y ;

Matsu-ura, T ;

Makino, Y ;

Masani, A ;

Okazaki, K ;

Morishita, T ;

Tamura, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (32) :22437-22444

[17] Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases - Site-directed mutagenesis of the ATP-dependent protease FtsH [J].

Karata, K ;

Inagawa, T ;

Wilkinson, AJ ;

Tatsuta, T ;

Ogura, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) :26225-26232

[18] Protein fold recognition using sequence profiles and its application in structural genomics [J].

Koonin, EV ;

Wolf, YI ;

Aravind, L .

ADVANCES IN PROTEIN CHEMISTRY, VOL 54, 2000, 54 :245-275

[19] 2 COMPLEMENTARY APPROACHES TO STUDY PEROXISOME BIOGENESIS IN SACCHAROMYCES-CEREVISIAE - FORWARD AND REVERSED GENETICS [J].

KUNAU, WH ;

BEYER, A ;

FRANKEN, T ;

GOTTE, K ;

MARZIOCH, M ;

SAIDOWSKY, J ;

SKALETZROROWSKI, A ;

WIEBEL, FF .

BIOCHIMIE, 1993, 75 (3-4) :209-224

[20] Classification and evolution of P-loop GTPases and related ATPases [J].

Leipe, DD ;

Wolf, YI ;

Koonin, EV ;

Aravind, L .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 317 (01) :41-72

← 1 2 3 4 5 →