CuSO4-Catalyzed Direct One-Pot Synthesis of Terminal Propargylic Amines from Trimethylsilylacetylene, Amines and Aldehydes through Fluoride-Free Desilylation

被引：3

作者：

Liu, Xiaoping ^{[1
]}

Yin, Xiaoxin ^{[1
]}

Liu, Qiqi ^{[1
]}

Lin, Bijin ^{[1
]}

Li, Yiqun ^{[1
,2
]}

机构：

[1] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

[2] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 31期

基金：

中国国家自然科学基金;

关键词：

aldehyde; amine; alkynylsilane; propargylic amine; copper catalyst; HIGHLY DIASTEREOSELECTIVE ADDITION; 3-COMPONENT COUPLING REACTIONS; COOPERATIVE CATALYTIC-SYSTEM; N-PROPARGYLAMINES; ALKYNES; FACILE; SONOGASHIRA; ACCESS; ALKYNYLSILANES; ALKYNYLATION;

D O I：

10.1002/slct.201701773

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct one-pot synthesis of terminal propargylic amines from trimethylsilylacetylene (TMS-acetylene) with variety of amines and aldehydes using anhydrous CuSO4 as a catalyst in absence of fluoride has been developed. This methodology is compatible with a variety of functional groups, and moderate to excellent yields are successfully achieved.

引用

页码：10215 / 10220

页数：6

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