Points to consider when doing a trial primarily involving the heart

被引：6

作者：

Allanore, Yannick ^{[1
,2
]}

Distler, Oliver ^{[3
]}

Walker, Ulrich A. ^{[4
]}

Khanna, Dinesh ^{[5
]}

Furst, Daniel E. ^{[6
]}

Meune, Christophe ^{[7
]}

机构：

[1] Paris Descartes Univ, Cochin Hosp, AP HP, Dept Rheumatol, Paris, France

[2] Paris Descartes Univ, Cochin Inst, AP HP, Paris, France

[3] Univ Hosp Zurich, Dept Rheumatol, Zurich, Switzerland

[4] Univ Basel, Rheumatol Dept, Basel, Switzerland

[5] Univ Michigan, Dept Med, Scleroderma Program, Ann Arbor, MI 48109 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Rheumatol, Los Angeles, CA 90095 USA

[7] Cochin Hosp, AP HP, Dept Cardiol, Paris, France

来源：

RHEUMATOLOGY | 2017年 / 56卷

关键词：

systemic sclerosis; heart; heart failure; arrhythmia; pericarditis; cardiac fibrosis; myocarditis; TISSUE-DOPPLER-ECHOCARDIOGRAPHY; SYSTEMIC-SCLEROSIS; CARDIAC-ARRHYTHMIAS; MYOCARDIAL-PERFUSION; CONDUCTION DEFECTS; INVOLVEMENT; SCLERODERMA; DYSFUNCTION; PREVALENCE; MORTALITY;

D O I：

10.1093/rheumatology/kex198

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiac involvement contributes to the severity of SSc and should carefully be investigated and managed in SSc patients. Although it is commonly sub-clinical, once symptomatic it has a poor prognosis. Several complementary tools (circulating biomarkers, electrocardiography, echocardiography, scintigraphy or MRI) allow the assessment of all the various cardiac structures (endocardium, myocardium and pericardium) and heart function. Treatment remains empirical but cardiac trials in SSc can add data to the treatment of this complication.

引用

页码：V12 / V16

页数：5

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