Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720

被引：15

作者：

Guo, Cui ^{[1
,2
]}

Lin, Xiu-Ping ^{[1
]}

Liao, Sheng-Rong ^{[1
]}

Yang, Bin ^{[1
]}

Zhou, Xue-Feng ^{[1
]}

Yang, Xian-Wen ^{[3
]}

Tian, Xin-Peng ^{[1
]}

Wang, Jun-Feng ^{[1
]}

Liu, Yong-Hong ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] State Ocean Adm, Inst Oceanog 3, State Key Lab Breeding Base Marine Genet Resourc, Key Lab Marine Genet Resources, Xiamen, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Deep-sea fungus; Penicillium sp; phenyl derivative; benzopyranone; MARINE-DERIVED FUNGUS; CONDENSED CHROMONES; DERIVATIVES; ANTIFUNGAL; ALKALOIDS; CITRINUM; SPONGE; METABOLITES; ANTIOXIDANT;

D O I：

10.1080/14786419.2018.1553880

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new compounds, 5-[2-hydroxypropane-1-yl]-2,6-dimethlbenzene-1,3-diol (1) and coniochaetone L (2), together with 19 known compounds (3-21), were isolated from a deep-sea fungus, Penicillium sp. SCSIO 06720. Their structures and absolute configurations were elucidated by detailed NMR, MS spectroscopic analyses, chiral-phase HPLC analysis, and electronic circular dichroism spectra. All the isolated compounds (1-21) were tested for their antibacterial and HIV latency-reversal activities. Among these compounds, compound 16 showed moderate antibacterial activities against Staphylococcus aureus ATCC 29213 and Methicillin-Resistant Staphylococcus Aureus-shh-1 with MIC values of 10.4 +/- 3.7 mu g/mL and 46.9 +/- 29.7 mu g/mL, respectively, which were comparable to that of the positive control ampicillin with MIC values of 0.5 +/- 0.4 mu g/mL and 2.7 +/- 0.9 mu g/mL, respectively.

引用

页码：1197 / 1205

页数：9

共 34 条

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