XIX. A transphyletic anti-infectious control strategy based on the killer phenomenon

被引：12

作者：

Conti, S ^{[1
]}

Magliani, W ^{[1
]}

Gerloni, M ^{[1
]}

Salati, A ^{[1
]}

Dieci, E ^{[1
]}

Arseni, S ^{[1
]}

Fisicaro, P ^{[1
]}

Polonelli, L ^{[1
]}

机构：

[1] Univ Parma, Ist Microbiol, Fac Med & Chirurg, I-43100 Parma, Italy

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 1998年 / 22卷 / 1-2期

关键词：

yeast killer phenomenon; candidiasis; pneumocystosis; tuberculosis; anti-idiotypic therapy; idiotypic vaccination;

D O I：

10.1111/j.1574-695X.1998.tb01200.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A strategy for the prevention and control of candidiasis, pneumocystosis, and tuberculosis, based on the idiotypic network of the yeast killer effect has been envisaged. Anti-idiotypic antibodies representing the internal image of a candidacidal, pneumocysticidal, and mycobactericidal killer toxin from Pichia anomala and idiotypes of killer toxin-neutralizing monoclonal antibodies mimicking the specific cell wall receptor of sensitive microorganisms might provide a unique approach for engineering innovative antibiotics and vaccines active against taxonomically unrelated pathogenic microorganisms. The rationale of the strategy relies on a phenomenon of microbial competition which has been mutated by the immune system in the response to natural infections. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：151 / 161

页数：11

共 61 条

[1]

[Anonymous], 1997, CLIN MICROBIOL REV

[2] Vaccine- and antigen-dependent type 1 and type 2 cytokine induction after primary vaccination of infants with whole-cell or acellular pertussis vaccines [J].