Oocyte maturation failure: a syndrome of bad eggs

被引：86

作者：

Beall, Stephanie ^{[2
]}

Brenner, Carol ^{[1
]}

Segars, James ^{[1
]}

机构：

[1] NICHD, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA

[2] Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Nashville, TN 37232 USA

来源：

FERTILITY AND STERILITY | 2010年 / 94卷 / 07期

关键词：

Oocyte maturation; oocyte arrest; meiotic arrest; sterility; METAPHASE-I ARREST; PROTEIN-KINASE-II; CYCLIN B1 DEGRADATION; MOUSE OOCYTES; MEIOTIC MATURATION; PROMOTING FACTOR; XENOPUS OOCYTES; CELL-CYCLE; MEIOSIS-I; PARTHENOGENETIC ACTIVATION;

D O I：

10.1016/j.fertnstert.2010.02.037

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

To show that disruption of meiotic competence results in cell cycle arrest, and the production of immature oocytes that are not capable of fertilization. Through an extensive review of animal studies and clinical case reports, we define the syndrome of oocyte maturation failure as a distinct oocyte disorder, present a classification system based on clinical parameters, and discuss the potential molecular origins for the disease. (Fertil Steril (R) 2010;94:2507-13. (C) 2010 by American Society for Reproductive Medicine.)

引用

页码：2507 / 2513

页数：7