Brain state-dependent recruitment of high-frequency oscillations in the human hippocampus

被引:16
作者
Billeke, Pablo [6 ]
Ossandon, Tomas [1 ,2 ]
Stockle, Marcelo [1 ,2 ]
Perrone-Bertolotti, Marcela [7 ]
Kahane, Philippe [5 ]
Lachaux, Jean-Philippe [3 ,4 ]
Fuentealba, Pablo [1 ,2 ]
机构
[1] Pontificia Univ Catolica Chile, Fac Med, Ctr Interdisciplinario Neurociencia, Santiago, Chile
[2] Pontificia Univ Catolica Chile, Fac Med, Dept Psiquiatria, Lab Circuitos Neuronales, Santiago, Chile
[3] CNRS, INSERM, U1028,Lyon Neurosci Res Ctr, UMR5292,Brain Dynam & Cognit Team, Lyon, France
[4] Univ Claude Bernard, Lyon, France
[5] CHU Grenoble, INSERM, Dept Neurol, U704, Grenoble, France
[6] Univ Desarrollo, Fac Gobierno, Ctr Invest Complejidad Social, Div Neurociencia, Santiago, Chile
[7] Univ Grenoble Alpes, CNRS, LPNC, UMR 51055105,Dept Psychol, Grenoble, France
关键词
Intracortical EEG; Hippocampus; Ripples; SHARP-WAVE RIPPLES; EPILEPTIC HIPPOCAMPUS; THETA-OSCILLATIONS; GAMMA OSCILLATIONS; SLOW OSCILLATIONS; SPATIAL MEMORY; NETWORK; SLEEP; TASK; CORTEX;
D O I
10.1016/j.cortex.2017.06.002
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Ripples are high-frequency bouts of coordinated hippocampal activity believed to be crucial for information transfer and memory formation. We used intracortical macro electrodes to record neural activity in the human hippocampus of awake subjects undergoing surgical treatment for refractory epilepsy and distinguished two populations of ripple episodes based on their frequency spectrum. The phase-coupling of one population, slow ripples (90-110 Hz), to cortical delta oscillations was differentially modulated by cognitive task; whereas the second population, fast ripples (130-170 Hz), was not seemingly correlated to local neural activity. Furthermore, as cognitive tasks changed, the ongoing coordination of neural activity associated to slow ripples progressively augmented along the parahippocampal axis. Thus, during resting states, slow ripples were coordinated in restricted hippocampal territories; whereas during active states, such as attentionally-demanding tasks, high frequency activity emerged across the hippocampus and parehippocampal cortex, that was synchronized with slow ripples, consistent with ripples supporting information transfer and coupling anatomically distant regions. Hence, our results provide further evidence of neural diversity in hippocampal high-frequency oscillations and their association to cognitive processing in humans. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:87 / 99
页数:13
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