Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats

被引：72

作者：

Birari, Rahul ^{[1
]}

Javia, Vishal ^{[1
]}

Bhutani, Kamlesh Kumar ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Nat Prod, Mohali 160062, Punjab, India

来源：

FITOTERAPIA | 2010年 / 81卷 / 08期

关键词：

Obesity; Murraya koenigii; Mahanimbine; Lipid; HFD; CARBAZOLE ALKALOIDS; STRATEGIES; DRUGS;

D O I：

10.1016/j.fitote.2010.07.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The dichloromethane (MKD) and ethyl acetate (MKE) extracts of Murraya koenigii leaves significantly reduced the body weight gain, plasma total cholesterol (TC) and triglyceride (TG) levels significantly when given orally at a dose of 300 mg/kg/day to the high fat diet (HFD) induced obese rats for 2 weeks. The observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them. Mahanimbine (1) when given orally (30 mg/kg/day) also significantly lowered the body weight gain as well as plasma TC and TG levels. These findings demonstrate the excellent pharmacological potential of mahanimbine to prevent obesity. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1129 / 1133

页数：5

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