Catalyst-free three-component reaction between 2-aminopyridines (or 2-aminothiazoles), aldehydes, and isocyanides in water

被引:118
作者
Adib, Mehdi
Mahdavi, Mohammad
Noghani, Mahsa Alizadeh
Mirzaei, Peiman
机构
[1] Univ Tehran, Univ Coll Sci, Sch Chem, Tehran, Iran
[2] Shahid Beheshti Univ, Dept Chem, Tehran, Iran
关键词
imidazo[1,2-a]pyridines; imidazo[2,1-b][1,3]thiazoles; isocyanides; three-component reactions; catalyst-free synthesis in water;
D O I
10.1016/j.tetlet.2007.08.049
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A catalyst-free and convenient protocol is described for the preparation of 3-aminoimidazo[1,2-a]pyridines and 5-aminoimidazo[2,1-b][1,3]thiazoles via three-component reactions between 2-aminopyridines or 2-aminothiazoles, aldehydes, and isocyanides in water in good to excellent yields. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:7263 / 7265
页数:3
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