Mapping gray matter volume and cortical thickness in Alzheimer's disease

被引：1
|
作者：
Guo, Xiaojuan [1 ,2 ]
Li, Ziyi [1 ]
Chen, Kewei [3 ,4 ]
Yao, Li [1 ,2 ]
Wang, Zhiqun [5 ]
Li, Kuncheng [5 ]
机构：
[1] Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China
[2] Beijing Normal Univ, Inst Cognit Neurosci & Learning, Beijing 100875, Peoples R China
[3] Banner Alzheimers Inst, Phoenix, AZ 85006 USA
[4] Banner Good Samaritan PET Ctr, Phoenix, AZ 85006 USA
[5] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
来源：
MEDICAL IMAGING 2010: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING | 2010年 / 7626卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's Disease; Cortical Thickness; Gray Matter; MRI; VBM; VOXEL-BASED MORPHOMETRY; SURFACE-BASED ANALYSIS; PATTERNS;
D O I：
10.1117/12.844070
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Gray matter volume and cortical thickness are two important indices widely used to detect neuropathological changes in brain structural magnetic resonance imaging. Using optimized voxel-based morphometry (VBM) protocol and surface-based cortical thickness measure, this study comprehensively investigated the regional changes in cortical gray matter volume and cortical thickness in Alzheimer's disease (AD). Thirteen patients with AD and fourteen age-and gender-matched healthy controls were included in this study. Results showed that voxel-based gray matter volume and cortical thickness reductions were highly correlated in the temporal lobe and its medial structure in AD. Moreover significant reduced cortical regions of gray matter volume were obviously more than that of cortical thickness. These findings suggest that gray matter volume and cortical thickness, as two important imaging markers, are effective indices for detecting the neuroanatomical alterations and help us understand the neuropathology from different views in AD.
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页数：9
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