Discovery of potent antiviral (HSV-1) quinazolinones and initial structure-activity relationship studies

被引：25

作者：

Brown, Carla E. ^{[1
]}

Kong, Tiffany ^{[1
]}

McNulty, James ^{[1
]}

D'Aiuto, Leonardo ^{[2
]}

Williamson, Kelly ^{[2
]}

McClain, Lora ^{[2
]}

Piazza, Paolo ^{[2
]}

Nimgaonkar, Vishwajit L. ^{[2
]}

机构：

[1] McMaster Univ, Dept Chem & Chem Biol, Hamilton, ON L8S 4M1, Canada

[2] Univ Pittsburgh, Dept Psychiat, WPIC, Sch Med, Pittsburgh, PA 15213 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 20期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Quinazolinone; Multi component coupling; Antiviral; HSV-1; Herpesvirus; SIMPLEX-VIRUS TYPE-1; ACID-CATALYZED CYCLOCONDENSATION; C BOND-CLEAVAGE; BIOLOGICAL EVALUATION; ANTHRANILAMIDES; INFECTIONS; INHIBITION; ALDEHYDES; OXIDANT; AGENTS;

D O I：

10.1016/j.bmcl.2017.09.026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The discovery of antiviral activity of 2,3-disubstituted quinazolinones, prepared by a one-pot, three-component condensation of isatoic anhydride with amines and aldehydes, against Herpes Simplex Virus (HSV)-1 is reported. Sequential iterative synthesis/antiviral assessment allowed structure-activity relationship (SAR) generation revealing synergistic structural features required for potent anti-HSV-1 activity. The most potent derivatives show greater efficacy than acyclovir against acute HSV-1 infections in neurons and minimal toxicity to the host. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：4601 / 4605

页数：5

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