Globalization, as a process that brings a continuous increase in international connection, can be seen in all areas such as economics, politics, culture, the environment and so on. The aspect of globalization appears mainly in the possibility of the Slovak Republic to use resources from the European Union budget to support the innovation potential of small and medium-sized enterprises. Due to the impact of globalization, individual countries are becoming more and more connected and create associations and groups that take on the individual competences and responsibilities in the decision-making process about the redistribution of resources between its members and thus between the entrepreneurs themselves, citizens. The main disadvantage of SMEs is limited access to capital that greatly affects the use of their innovation potential, it is the role of the government to actively participate in creating such conditions for an entrepreneurial environment that will ensure a healthy competitive environment to strengthen innovation and research activities and to strengthen the competitiveness of small and medium-sized enterprises in the domestic and foreign markets. SMEs can quickly and efficiently respond to customer demands and consequently respond to changes resulting from market changes. The current economy in the period of globalization requires, in particular, to support the innovative potential of SMEs and thereby increase the share of established research and innovation results not only in enterprises but also in economic practice. The main objective of the article is to evaluate support for research and innovation and comparing the use of EU money within V4.