Chemiluminescence-Generating Nanoreactor Formulation for Near-Infrared Imaging of Hydrogen Peroxide and Glucose Level in vivo

被引：130

作者：

Lim, Chang-Keun ^{[1
]}

Lee, Yong-Deok ^{[1
]}

Na, Jinhee ^{[1
]}

Oh, Jung Min ^{[2
]}

Her, Song ^{[2
]}

Kim, Kwangmeyung ^{[1
]}

Choi, Kuiwon ^{[1
]}

Kim, Sehoon ^{[1
]}

Kwon, Ick Chan ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Biomed Sci Ctr, Seoul 136791, South Korea

[2] Korea Basic Sci Inst, Chuncheon Ctr, Div Analyt Bioimaging, Chunchon 200701, Gangwon Do, South Korea

来源：

ADVANCED FUNCTIONAL MATERIALS | 2010年 / 20卷 / 16期

关键词：

BLOOD-GLUCOSE; BIOLUMINESCENCE; MICELLES; TUMOR;

D O I：

10.1002/adfm.201000780

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water-dispersed all-in-one nanoprobes composed of densely integrated peroxyoxalate fuel and a cyanine dye are formulated to optimize the nanoscopic chemiluminescence reaction. It is demonstrated that the chemiluminescent nanoformulation can generate bright near-infrared signal in response to external hydrogen peroxide that is biologically implicated with cell signaling and diseases. Successful imaging of endogenously overproduces hydrogen peroxide and indirect determination of glucose level in vivo with the chemiluminescent nanoprobes offers an opportunity for early diagnosis of diseases.

引用

页码：2644 / 2648

页数：5

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