A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

被引：1509

作者：

Taunton, J

Hassig, CA

Schreiber, SL

机构：

[1] HARVARD UNIV, HOWARD HUGHES MED INST, DEPT CHEM & BIOL CHEM, CAMBRIDGE, MA 02138 USA

[2] HARVARD UNIV, HOWARD HUGHES MED INST, DEPT MOLEC & CELLULAR BIOL, CAMBRIDGE, MA 02138 USA

来源：

SCIENCE | 1996年 / 272卷 / 5260期

关键词：

D O I：

10.1126/science.272.5260.408

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity. Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library. As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription.

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页码：408 / 411

页数：4

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