A series of novel 1H-dibenzo[a,c]carbazole derivatives were synthesized in good yield through reaction of methyl 7-oxo-dehydroabietate with a variety of substituted phenylhydrazines The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, MS spectral studies and elemental analysis. All compounds were investigated for their activity against four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescens) and three fungi (Trichophyton rubrum, Candida albicans and Aspergillus niger) Among the compound tested, 6d, 6e, 6f and 6m exhibited pronounced antibacterial activities and 6e and 6m also showed moderate antifungal activities. Particularly, 6d exhibited stronger antibacterial activity against B. subtilis comparable to positive control. (C) 2010 Elsevier Masson SAS All rights reserved.
机构:
Univ Rouen, IRCOF, CNRS, UMR 6014, F-76821 Mont St Aignan, France
Univ Rouen, FR 3038, F-76821 Mont St Aignan, France
INSA, F-76821 Mont St Aignan, FranceCelal Bayar Univ, Sci & Arts Fac, Dept Chem, TR-45030 Muradiye, Manisa, Turkey
机构:
Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R ChinaChinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China
Rao, Xiaoping
Song, Zhanqian
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Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R ChinaChinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China
Song, Zhanqian
He, Ling
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China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R ChinaChinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China
He, Ling
Jia, Weihong
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Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R ChinaChinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China