Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid

被引：83
|
作者：
Gu, Wen [1 ]
Wang, Shifa [1 ]
机构：
[1] Nanjing Forestry Univ, Dept Forestry Chem Engn, Coll Chem Engn, Nanjing 210037, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 10期
基金：
中国国家自然科学基金;
关键词：
1H-dibenzo[a; c]carbazole; Dehydroabietic acid; Synthesis; Antibacterial activity; Antifungal activity; MURRAYA-KOENIGII; CARBAZOLE; ALKALOIDS; DESIGN; AGENTS;
D O I：
10.1016/j.ejmech.2010.07.038
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel 1H-dibenzo[a,c]carbazole derivatives were synthesized in good yield through reaction of methyl 7-oxo-dehydroabietate with a variety of substituted phenylhydrazines The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, MS spectral studies and elemental analysis. All compounds were investigated for their activity against four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescens) and three fungi (Trichophyton rubrum, Candida albicans and Aspergillus niger) Among the compound tested, 6d, 6e, 6f and 6m exhibited pronounced antibacterial activities and 6e and 6m also showed moderate antifungal activities. Particularly, 6d exhibited stronger antibacterial activity against B. subtilis comparable to positive control. (C) 2010 Elsevier Masson SAS All rights reserved.
引用
收藏
页码：4692 / 4696
页数：5
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