Antimalarial Drug Resistance: A Threat to Malaria Elimination

被引：293

作者：

Menard, Didier ^{[1
]}

Dondorp, Arjen ^{[2
]}

机构：

[1] Inst Pasteur Cambodia, Malaria Mol Epidemiol Unit, Phnom Penh 12201, Cambodia

[2] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok 73170, Thailand

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2017年 / 7卷 / 07期

基金：

英国惠康基金;

关键词：

PLASMODIUM-FALCIPARUM MALARIA; DIHYDROARTEMISININ-PIPERAQUINE FAILURE; IN-VITRO RESISTANCE; RICH PROTEIN-II; ARTEMISININ RESISTANCE; MULTIDRUG-RESISTANCE; WESTERN CAMBODIA; EX-VIVO; CHLOROQUINE RESISTANCE; MEFLOQUINE RESISTANCE;

D O I：

10.1101/cshperspect.a025619

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins has emerged in the Greater Mekong Subregion. Concomitant emergence of partner drug resistance is now causing high ACT treatment failure rates in several areas. Genetic markers for artemisinin resistance and several of the partner drugs have been established, greatly facilitating surveillance. Single point mutations in the gene coding for the Kelch propeller domain of the K13 protein strongly correlate with artemisinin resistance. Novel regimens and strategies using existing antimalarial drugs will be needed until novel compounds can be deployed. Elimination of artemisinin resistance will imply elimination of all falciparum malaria from the same areas. In vivax malaria, chloroquine resistance is an increasing problem.

引用

页码：1 / 24

页数：24

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