PRAD1/cyclin D1 gene overexpression in mantle cell lymphoma

被引：17
作者：
Oka, K
Ohno, T
Yamaguchi, M
Mahmud, N
Miwa, H
Kita, K
Shiku, H
Shirakawa, S
机构：
[1] Second Dept. of Internal Medicine, Mie University, School of Medicine, Edobashi Tsu, Mie
[2] Second Dept. of Internal Medicine, Mie University, School of Medicine, 2-174 Edobashi, Tsu, Mie
来源：
LEUKEMIA & LYMPHOMA | 1996年 / 21卷 / 1-2期
关键词：
mantle cell lymphoma; PRAD1; cyclin D1; Bcl-1;
D O I：
10.3109/10428199609067577
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The t(11;14) (q13;q32) translocation and its molecular counterpart Bcl-1 rearrangement are consistent features of mantle cell lymphoma (MCL). This translocation activates the PRAD1/cyclin D1 gene that is considered to be the Bcl-1 oncogene. PRAD1/cyclin D1 gene overexpression is closely associated with MCL. The PRAD1/cyclin D1 protein is localized to the nucleus, and the strong correlation between PRAD1/cyclin D1 and MCL is also found in the protein level. This finding indicates that PRAD1/cyclin D1 expression is a highly specific and sensitive molecular marker for MCL. This gene may function as an oncogene in the malignant transformation of cells.
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页码：37 / 42
页数：6
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