The Pathological Effects of Melamine and Cyanuric Acid in the Diet of Walking Catfish (Clarius batrachus)

被引：17
作者：
Pirarat, N. [1 ]
Katagiri, T. [2 ]
Chansue, N. [3 ]
Ponpornpisit, A. [3 ]
Endo, M. [2 ]
Maita, M. [2 ]
机构：
[1] Chulalongkorn Univ, Fac Vet Sci, Dept Pathol, Bangkok 10330, Thailand
[2] Tokyo Univ Marine Sci & Technol, Lab Fish Hlth Management, Tokyo, Japan
[3] Chulalongkorn Univ, Fac Vet Sci, Dept Vet Med, Bangkok 10330, Thailand
来源：
JOURNAL OF COMPARATIVE PATHOLOGY | 2012年 / 147卷 / 2-3期
关键词：
cyanuric acid; melamine; toxicity; walking catfish; RENAL-FAILURE; DOGS; DERIVATIVES; TOXICITY; TROUT; CATS; PIGS;
D O I：
10.1016/j.jcpa.2011.12.008
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The toxicity of melamine and its analogue in man and animals has been reported widely. The aim of the present study was to examine the pathological effects of feeding melamine and cyanuric acid, separately or in combination, to walking catfish (Clarius batrachus). The catfish developed darkening of the skin as early as 3 days post feeding. Melamine-related crystals were distributed multifocally throughout the liver, kidney, heart, spleen and corpuscle of Stannius of fish fed melamine and cyanuric acid in combination. Oil red 0 staining and electron microscopy revealed that the melamine-related crystals had structure resembling that of plastic polymer crystals. Elevations in the serum concentrations of alanine transaminase, aspartate transaminase, creatinine and uric acid were related to the crystal-associated granulomatous inflammation in the liver and kidney of affected fish. None of the catfish died during the 2-week experiment. Melamine and cyanuric acid are therefore systemically toxic to fish in addition to causing renal crystal formation and renal damage as seen in man and animals. The finding of extrarenal crystals implies that the metabolism and biotransformation of these toxic compounds should be further investigated in aquatic animals. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：259 / 266
页数：8
相关论文
共 20 条
  • [11] UROLITHIASIS AND BLADDER CARCINOGENICITY OF MELAMINE IN RODENTS
    MELNICK, RL
    BOORMAN, GA
    HASEMAN, JK
    MONTALI, RJ
    HUFF, J
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 72 (02) : 292 - 303
  • [12] Melamine- and Cyanuric Acid-Associated Renal Failure in Pigs in Thailand
    Nilubol, D.
    Pattanaseth, T.
    Boonsri, K.
    Pirarat, N.
    Leepipatpiboon, N.
    [J]. VETERINARY PATHOLOGY, 2009, 46 (06) : 1156 - 1159
  • [13] Assessment of melamine and cyanuric acid toxicity in cats
    Puschner, Birgit
    Poppenga, Robert H.
    Lowenstine, Linda J.
    Filigenzi, Michael S.
    Pesavento, Patricia A.
    [J]. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2007, 19 (06) : 616 - 624
  • [14] Ramusino M C, 1982, Acta Embryol Morphol Exp, V3, P41
  • [15] Residue depletion of melamine and cyanuric acid in catfish and rainbow trout following oral administration
    Reimschuessel, R.
    Evans, E.
    Andersen, W. C.
    Turnipseed, S. B.
    Karbiwnyk, C. M.
    Mayer, T. D.
    Nochetto, C.
    Rummel, N. G.
    Gieseker, C. M.
    [J]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2010, 33 (02) : 172 - 182
  • [16] Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs
    Reimschuessel, Renate
    Gieseker, Charles M.
    Miller, Ron A.
    Ward, Jeffrey
    Boehmer, Jamie
    Rummel, Nathan
    Heller, David N.
    Nochetto, Cristina
    de Alwis, G. K. Hemakanthi
    Bataller, Neal
    Andersen, Wendy C.
    Turnipseed, Sherri B.
    Karbiwnyk, Christine M.
    Satzger, Duane
    Crowe, John B.
    Wilber, Nancy R.
    Reinhard, Mary K.
    Roberts, John F.
    Witkowski, Mark R.
    [J]. AMERICAN JOURNAL OF VETERINARY RESEARCH, 2008, 69 (09) : 1217 - 1228
  • [17] HISTOLOGIC IDENTIFICATION OF POLYETHYLENE WEAR DEBRIS USING OIL RED-O STAIN
    SCHMALZRIED, TP
    JASTY, M
    ROSENBERG, A
    HARRIS, WH
    [J]. JOURNAL OF APPLIED BIOMATERIALS, 1993, 4 (02) : 119 - 125
  • [18] Characterization of melamine-containing and calcium oxalate crystals in three dogs with suspected pet food-induced nephrotoxicosis
    Thompson, M. E.
    Lewin-Smith, M. R.
    Kalasinsky, V. F.
    Pizzolato, K. M.
    Fleetwood, M. L.
    Mcelhaney, M. R.
    Johnson, T. O.
    [J]. VETERINARY PATHOLOGY, 2008, 45 (03) : 417 - 426
  • [19] Metabonomic Evaluation of Melamine-Induced Acute Renal Toxicity in Rats
    Xie, Guoxiang
    Zheng, Xiaojiao
    Qi, Xin
    Cao, Yu
    Chi, Yi
    Su, Mingming
    Ni, Yan
    Qiu, Yunping
    Liu, Yumin
    Li, Houkai
    Zhao, Aihua
    Jia, Wei
    [J]. JOURNAL OF PROTEOME RESEARCH, 2010, 9 (01) : 125 - 133
  • [20] Retrospective Study of Melamine/Cyanuric Acid-Induced Renal Failure in Dogs in Korea between 2003 and 2004
    Yhee, J. -Y.
    Brown, C. A.
    Yu, C. -H.
    Kim, J. -H.
    Poppenga, R.
    Sur, J. -H.
    [J]. VETERINARY PATHOLOGY, 2009, 46 (02) : 348 - 354
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