Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9

被引：51

作者：

Huang, Guan-Jhong ^{[2
]}

Deng, Jeng-Shyan ^{[3
]}

Chiu, Chuan-Sung ^{[4
]}

Liao, Jung-Chun ^{[1
]}

Hsieh, Wen-Tsong ^{[5
]}

Sheu, Ming-Jyh ^{[1
]}

Wu, Chieh-Hsi ^{[1
]}

机构：

[1] China Med Univ, Sch Pharm, Coll Pharm, Taichung 404, Taiwan

[2] China Med Univ, Sch Chinese Pharmaceut Sci & Chinese Med Resource, Coll Pharm, Taichung 404, Taiwan

[3] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413, Taiwan

[4] Hsin Sheng Coll Med Care & Management, Dept Nursing, Tao Yuan 325, Taiwan

[5] China Med Univ, Dept Pharmacol, Taichung 404, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷

关键词：

TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE; CARBON-TETRACHLORIDE; MATRIX METALLOPROTEINASES; INDUCED HEPATOTOXICITY; ANTIOXIDANT ACTIVITY; FACTOR-ALPHA; CELLS; ENZYMES; INJURY;

D O I：

10.1155/2012/480714

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The hepatoprotective potential of hispolon against carbon tetrachloride (CCl4)-induced liver damage was evaluated in preventive models in rats. Male rats were intraperitoneally treated with hispolon or silymarin once daily for 7 consecutive days. One hour after the final hispolon or silymarin treatment, the rats were injected with CCl4. Administration with hispolon or silymarin significantly decreased the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in serumand increased the activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and glutathione (GSH) content and decreased the malondialdehyde (MDA) content in liver compared with CCl4-treated group. Liver histopathology also showed that hispolon reduced the incidence of liver lesions induced by CCl4. In addition, hispolon decreased nitric oxide (NO) production and tumor necrosis factor (TNF-alpha), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) activation in CCl4-treated rats. We also examined the involvement of matrix metalloproteinase (MMP)-9 in the development of CCl4-induced liver damage in rats. Hispolon inhibited the expression of MMP-9 protein, indicating that MMP-9 played an important role in the development of CCl4-induced rat liver damage. Therefore, we speculate that hispolon protects rats from liver damage through their prophylactic redox balancing ability and anti-inflammation capacity.

引用

页数：12

共 38 条

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