An Efficient Total Synthesis of Resokaempferol 3-O-β-D-Glucoside

被引：1

作者：

Ren, Xuhong ^{[2
]}

Wang, Jingjing ^{[2
]}

Shen, Lin-Lan ^{[2
]}

Li, Wei ^{[2
]}

Muraoka, Osamu ^{[1
]}

Cheng, Maosheng ^{[2
]}

机构：

[1] Kinki Univ, Sch Pharmaceut Sci, Osaka 5778502, Japan

[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Key Lab Struct Based Drugs Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

来源：

CHEMISTRY LETTERS | 2011年 / 40卷 / 10期

关键词：

BIOLOGICAL EVALUATION; QUERCETIN; KAEMPFEROL; FLAVONOIDS; GLYCOSIDES; AGENTS; DERIVATIVES; POTENT; RATS;

D O I：

10.1246/cl.2011.1135

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Resokaempferol 3-O-beta-D-glucoside, an artificial flavonol glycoside, was synthesized from 2,4-dihydroxyacetophenone in six steps and 40% overall yield via an efficient glycosylation method using NaH.

引用

页码：1135 / 1137

页数：3

共 28 条

[1] Regio- and stereoselective synthesis of the major metabolite of quercetin, quercetin-3-O-β-D-glucuronide
Bouktaib, M
Atmani, A
Rolando, C
[J]. TETRAHEDRON LETTERS, 2002, 43 (35) : 6263 - 6266
[2] Progress in the research on naturally occurring flavones and flavonols: An overview
Brahmachari, G
Gorai, D
[J]. CURRENT ORGANIC CHEMISTRY, 2006, 10 (08) : 873 - 898
[3] Binding interaction of quereetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro:: Structure-activity relationship studies reveal salient pharmacophore features
Chen, Lili
Li, Jian
Luo, Cheng
Liu, Hong
Xu, Weijun
Chen, Gang
Liew, Oi Wah
Zhu, Weiliang
Puah, Chum Mok
Shen, Xu
Jiang, Hualiang
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (24) : 8295 - 8306
[4] Synthesis and biological evaluation of flavonoids as vasorelaxant agents
Chen, ZW
Hu, YZ
Wu, HH
Jiang, HD
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (15) : 3949 - 3952
[5] Flavonoids with an Oligopolysulfated Moiety A New Class of Anticoagulant Agents
Correia-da-Silva, Marta
Sousa, Emilia
Duarte, Barbara
Marques, Franklim
Carvalho, Felix
Cunha-Ribeiro, Luis M.
Pinto, Madalena M. M.
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (01) : 95 - 106
[6] PHASE-TRANSFER-CATALYZED SYNTHESIS OF FLAVONOID GLYCOSIDES
DEMETZOS, C
SKALTSOUNIS, AL
TILLEQUIN, F
KOCH, M
[J]. CARBOHYDRATE RESEARCH, 1990, 207 (01) : 131 - 137
[7] Total synthesis of quercetin 3-sophorotrioside
Du, YG
Wei, GH
Linhardt, RJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2004, 69 (06) : 2206 - 2209
[8] Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents
Hossion, Abugafar M. L.
Otsuka, Nao
Kandahary, Rafiya K.
Tsuchiya, Tomofusa
Ogawa, Wakano
Iwado, Akimasa
Zamami, Yoshito
Sasaki, Kenji
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (17) : 5349 - 5352
[9] Jung SangHoon Jung SangHoon, 2004, Natural Product Sciences, V10, P35
[10] Regiospecific synthesis of quercetin O-β-D-glucosylated and O-β-D-glucuronidated isomers
Kajjout, Mohammed
Rolando, Christian
[J]. TETRAHEDRON, 2011, 67 (25) : 4731 - 4741

← 1 2 3 →