共 42 条
Enhanced oral bioavailability of oligomeric proanthocyanidins by a self-double-emulsifying drug delivery system
被引:10
作者:
Tian, Yuan
[1
]
Mao, Xinyu
[1
]
Sun, Rui
[1
]
Zhang, Ming
[1
]
Xia, Qiang
[2
]
机构:
[1] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing, Peoples R China
[2] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing, Peoples R China
关键词:
bioavailability;
oligomeric proanthocyanidin;
self-double-emulsifying drug delivery system;
solid form;
stability;
IN-VITRO;
CONTROLLED-RELEASE;
EMULSIONS;
CARRIER;
FORMULATIONS;
SOLUBILITY;
ABSORPTION;
PROTECTION;
DIGESTION;
VESICLES;
D O I:
10.1002/fsn3.1673
中图分类号:
TS2 [食品工业];
学科分类号:
0832 ;
摘要:
The present study aims at the formulation and evaluation of solid self-double-emulsifying drug delivery system (SDEDDS) to increase the bioavailability of oligomeric proanthocyanidin (OPC). The formulation is prepared through two-step method and is able to form water-in-oil-in-water (W/O/W) double emulsions after diluted with aqueous medium while keeping the drug in inner water phase. Solid-state characterization is performed by DSC and X-ray powder diffraction. Furthermore, antioxidant capacity shows that OPC is preserved by the solid SDEDDS. OPC-SDEDDS exhibit sustained release of OPC under the conditions mimicking gastrointestinal tract. The result shows that bioaccessibility of OPC is improved after incorporating into SDEDDS formulation compared to pure drug. The proposed SDEDDS is a promising carrier strategy for delivering the hydrophilic compounds with low-oral bioavailability.
引用
收藏
页码:3814 / 3825
页数:12
相关论文