An Updated View on the Rck Invasin of Salmonella: Still Much to Discover

被引:43
作者
Mambu, Julien [1 ,2 ]
Virlogeux-Payant, Isabelle [1 ,2 ]
Holbert, Sebastien [1 ,2 ]
Grepinet, Olivier [1 ,2 ]
Velge, Philippe [1 ,2 ]
Wiedemann, Agnes [1 ,2 ]
机构
[1] INRA, UMR1282, Infectiol & Sante Publ, Nouzilly, France
[2] Univ Tours, UMR1282, Infectiol & Sante Publ, Tours, France
基金
欧盟第七框架计划;
关键词
Salmonella; gene expression; outer membrane protein; membrane receptor; bacterial internalization; cell signaling; bacterial behavior; organ colonization; ENTERICA SEROVAR TYPHIMURIUM; GROWTH-FACTOR RECEPTOR; VIRULENCE PLASMID; SERUM RESISTANCE; ENTERITIDIS; ACTIVATION; FAMILY; IDENTIFICATION; EXPRESSION; SEQUENCE;
D O I
10.3389/fcimb.2017.00500
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Salmonella is a facultative intracellular Gram-negative bacterium, responsible for a wide range of food- and water-borne diseases ranging from gastroenteritis to typhoid fever depending on hosts and serotypes. Salmonella thus represents a major threat to public health. A key step in Salmonella pathogenesis is the invasion of phagocytic and non-phagocytic host cells. To trigger its own internalization into non-phagocytic cells, Salmonella has developed different mechanisms, involving several invasion factors. For decades, it was accepted that Salmonella could only enter cells through a type three secretion system, called T3SS-1. Recent research has shown that this bacterium expresses outer membrane proteins, such as the Rck protein, which is able to induce Salmonella entry mechanism. Rck mimics natural host cell ligands and triggers engulfment of the bacterium by interacting with the epidermal growth factor receptor. Salmonella is thus able to use multiple entry pathways during the Salmonella infection process. However, it is unclear how and when Salmonella exploits the T3SS-1 and Rck entry mechanisms. As a series of reviews have focused on the T3SS-1, this review aims to describe the current knowledge and the limitations of our understanding of the Rck outer membrane protein. The regulatory cascade which controls Rck expression and the molecular mechanisms underlying Rck-mediated invasion into cells are summarized. The potential role of Rck-mediated invasion in Salmonella pathogenesis and the intracellular behavior of the bacteria following a Salmonella Rck-dependent entry are discussed.
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页数:10
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共 84 条
[11]   Genomic Characterisation of Invasive Non-Typhoidal Salmonella enterica Subspecies enterica Serovar Bovismorbificans Isolates from Malawi [J].
Bronowski, Christina ;
Fookes, Maria C. ;
Gilderthorp, Ruth ;
Ashelford, Kevin E. ;
Harris, Simon R. ;
Phiri, Amos ;
Hall, Neil ;
Gordon, Melita A. ;
Wain, John ;
Hart, Charles A. ;
Wigley, Paul ;
Thomson, Nicholas R. ;
Winstanley, Craig .
PLOS NEGLECTED TROPICAL DISEASES, 2013, 7 (11)
[12]   Comprehensive Assignment of Roles for Salmonella Typhimurium Genes in Intestinal Colonization of Food-Producing Animals [J].
Chaudhuri, Roy R. ;
Morgan, Eirwen ;
Peters, Sarah E. ;
Pleasance, Stephen J. ;
Hudson, Debra L. ;
Davies, Holly M. ;
Wang, Jinhong ;
van Diemen, Pauline M. ;
Buckley, Anthony M. ;
Bowen, Alison J. ;
Pullinger, Gillian D. ;
Turner, Daniel J. ;
Langridge, Gemma C. ;
Turner, A. Keith ;
Parkhill, Julian ;
Charles, Ian G. ;
Maskell, Duncan J. ;
Stevens, Mark P. .
PLOS GENETICS, 2013, 9 (04)
[13]   Expression of Toll-Like Receptor 4 and Downstream Effectors in Selected Cecal Cell Subpopulations of Chicks Resistant or Susceptible to Salmonella Carrier State [J].
Chausse, Anne-Marie ;
Grepinet, Olivier ;
Bottreau, Elisabeth ;
Le Vern, Yves ;
Menanteau, Pierrette ;
Trotereau, Jerome ;
Robert, Vincent ;
Wu, Zhiguang ;
Kerboeuf, Dominique ;
Beaumont, Catherine ;
Velge, Philippe .
INFECTION AND IMMUNITY, 2011, 79 (08) :3445-3454
[14]   Identification of a domain in Rck, a product of the Salmonella typhimurium virulence plasmid, required for both serum resistance and cell invasion [J].
Cirillo, DM ;
Heffernan, EJ ;
Wu, L ;
Harwood, J ;
Fierer, J ;
Guiney, DG .
INFECTION AND IMMUNITY, 1996, 64 (06) :2019-2023
[15]   EVIDENCE FOR CLATHRIN MOBILIZATION DURING DIRECTED PHAGOCYTOSIS OF SHIGELLA-FLEXNERI BY HEP2 CELLS [J].
CLERC, PL ;
SANSONETTI, PJ .
MICROBIAL PATHOGENESIS, 1989, 7 (05) :329-336
[17]   Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine heal loop model and a murine model of infectious enterocolitis [J].
Coombes, BK ;
Coburn, BA ;
Potter, AA ;
Gomis, S ;
Mirakhur, K ;
Li, YL ;
Finlay, BB .
INFECTION AND IMMUNITY, 2005, 73 (11) :7161-7169
[18]   Bacterial invasion: The paradigms of enteroinvasive pathogens [J].
Cossart, P ;
Sansonetti, PJ .
SCIENCE, 2004, 304 (5668) :242-248
[19]   Binding of extracellular matrix laminin to Escherichia coli expressing the Salmonella outer membrane proteins Rck and PagC [J].
Crago, AM ;
Koronakis, V .
FEMS MICROBIOLOGY LETTERS, 1999, 176 (02) :495-501
[20]   Coordinate regulation of Salmonella enterica serovar Typhimurium invasion of epithelial cells by the arp2/3 complex and rho GTPases [J].
Criss, AK ;
Casanova, JE .
INFECTION AND IMMUNITY, 2003, 71 (05) :2885-2891