Classification and Nomenclature of CRISPR-Cas Systems: Where from Here?

被引：168

作者：

Makarova, Kira S. ^{[1
]}

Wolf, Yuri I. ^{[1
]}

Koonin, Eugene V. ^{[1
]}

机构：

[1] Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

来源：

CRISPR JOURNAL | 2018年 / 1卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CRYSTAL-STRUCTURE; CSM COMPLEX; DNA; EVOLUTION; NUCLEASE; RESTRICTION; DIVERSITY; ENDONUCLEASES; DEGRADATION; CLEAVAGE;

D O I：

10.1089/crispr.2018.0033

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

As befits an immune mechanism, CRISPR-Cas systems are highly variable with respect to Cas protein sequences, gene composition, and organization of the genomic loci. Optimal classification of CRISPR-Cas systems and rational nomenclature for CRISPR-associated genes are essential for further progress of CRISPR research. These are highly challenging tasks because of the complexity of CRISPR-Cas and their fast evolution, including frequent module shuffling, as well as the lack of universal markers for a consistent evolutionary classification. The complexity and variability of CRISPR-Cas systems necessitate a multipronged approach to classification and nomenclature. We present a brief summary of the current state of the art and discuss further directions in this area.

引用

页码：325 / 336

页数：12

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