Abibalsamins A and B, Two New Tetraterpenoids from Abies balsamea Oleoresin

被引：29

作者：

Lavoie, Serge ^{[1
]}

Legault, Jean ^{[1
]}

Gauthier, Charles ^{[1
,2
]}

Mshvildadze, Vakhtang ^{[1
]}

Mercier, Sylvain ^{[1
]}

Pichette, Andre ^{[1
]}

机构：

[1] Univ Quebec, Dept Sci Fondamentales, Lab Anal & Separat Essences Vegetales LASEVE, Chaire Rech Agents Anticanc Origine Nat, Chicoutimi, PQ G7H 2B1, Canada

[2] Univ Poitiers, Inst Chim IC2MP, UMR CNRS 7285, F-86022 Poitiers, France

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

BLACK SPRUCE; JACK PINE; WOOD; DITERPENES; BARK;

D O I：

10.1021/ol300237f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Abibalsamins A (1) and B (2), two unprecedented tetraterpenoids featuring a 3,4-seco-rearranged Ianostane system fused with a beta-myrcene lateral chain via a [4 + 2] Diels-Alder cycloaddition, were isolated from the oleoresin of Abies balsamea. Their structures were elucidated by means of extensive 20 NMR, IR, and MS spectroscopy analyses. The absolute configuration of 1 was determined by single-crystal X-ray diffraction. Both compounds exhibited significant cytotoxic activity against cancer cell lines.

引用

页码：1504 / 1507

页数：4

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