Significant Axial Elongation with Minimal Change in Refraction in 3-to 6-Year-Old Chinese Preschoolers The Shenzhen Kindergarten Eye Study

Purpose: To document the distribution of ocular biometry and to evaluate its associations with refraction in a group of Chinese preschoolers. Design: Population-based cross-sectional study. Participants: A total of 1133 preschoolers 3 to 6 years of age from 8 representative kindergartens. Methods: Biometric measurements including axial length (AL), anterior chamber depth (ACD), and corneal radius of curvature (CR) were obtained from partial-coherence laser interferometry (IOL Master; Carl Zeiss Meditec, Oberkochen, Germany) before cycloplegia. Lens power (LP) and AL-to-CR ratio were calculated. Cycloplegic refraction (3 drops of 1% cyclopentolate) was measured using an autorefractor (KR8800; Topcon Corp., Tokyo, Japan), and spherical equivalent refraction (SER) was calculated. Biometric and refractive parameters were assessed as a function of age and gender. Multiple regression analysis was performed to explore the associations between refraction and ocular biometry. Main Outcome Measures: Ocular biometric distributions and their relationships to refraction. Results: Among the 1127 children (99.5%) with successful cycloplegic refraction, mean SER was 1.37 +/- 0.63 diopters (D). Prevalence of myopia increased from 0% at 3 years of age to 3.7% (95% confidence interval, 1.0%6.5%) at 6 years of age. Biometric parameters followed Gaussian distributions with means of 22.39 +/- 0.68 mm for AL, 7.79 +/- 0.25 mm for CR, and 24.61 +/- 1.42 D for calculated LP; and non-Gaussian distributions with means of 3.34 +/- 0.24 mm for ACD and 2.88 +/- 0.06 for AL-to-CR ratio. Axial length, ACD, and AL-to-CR ratio increased from 3 to 6 years of age, CR remained stable, whereas LP declined. Overall, SER declined slightly. For the SER variance, AL explained 18.6% and AL-to-CR ratio explained 39.8%, whereas AL, CR, and LP accounted for 80.0% after adjusting for age and gender. Conclusions: Young Chinese children are predominantly mildly hyperopic, with a low prevalence of myopia by the age of 6 years. An increase of 1 mm in AL was associated with only 0.45 D of myopic change. Decreases in LP reduce the myopic shifts that normally would be associated with increases in AL, and thus play a key role in refractive development in this age group. (C) 2017 by the American Academy of Ophthalmology