PROTECTIVE EFFECT OF CURCUMIN ON DIFFERENT TISSUES OF RAINBOW TROUT (ONCORHYNCHUS MYKISS W., 1792) AGAINST EXPOSITION TO CHLORPHYRIFOS

In this study, protective effects of Curcumin (CUR) against Chlorphyrifos (CPF)-induced oxidative stress on blood serum, liver and gill tissues of rainbow trout (Oncorhynchus mykiss) were investigated. In the first group, normal water and recommended diet were used as the control group. The second fish group was exposed to water containing 0 040 mg/l CPF. The third fish group received only 0.5% (CUR1) and the fourth group received only 1% CUR (CUR2). The fifth group was exposed to water containing 0 040 mg/l CPF and received only 0.5% (CPF + CUR1). The sixth group was exposed to water containing 0 040 mg/l CPF, giving and received only 0.1% (CPF + CUR2). Samples were taken from the blood, liver and gill tissues and total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were measured. The supplementation of CUR with CPF attenuated the adverse effects of CPF intoxication by reducing TOS and OSI and increased TAC in serum and liver. These results showed that CPF, alone, increased oxidative stress in rainbow trout but CUR reduced oxidative stress alone or when combined with CPF in the serum and liver, but not in the gill.