The genetics of suicide: A critical review of molecular studies

被引：82

作者：

Brezo, Jelena ^{[1
]}

Klempan, Tim ^{[1
]}

Turecki, Gustavo ^{[1
]}

机构：

[1] McGill Grp Suicide Studies, Dept Psychiat, Montreal, PQ H4H 1R3, Canada

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 2008年 / 31卷 / 02期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/j.psc.2008.01.008

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Genetic epidemiology research has shown that genes contribute to suicide risk. Unfortunately, the first 30 years of candidate-based association studies have provided little information about the specific genetic contributors. This article reviews genetic association studies of suicidal phenotypes published to date. Possible theoretical, methodological, and operational challenges accounting for the modest success of association studies in the field are also discussed. The authors conclude that future research may benefit from using a more systematic and comprehensive selection of candidate genes and variants, examining gene-environment and gene-gene interactions, and investigating higher-order moderators.

引用

页码：179 / +

页数：26

共 199 条

[1] Suicide attempts and the tryptophan hydroxylase gene [J].

Abbar, M ;

Courtet, P ;

Bellivier, F ;

Leboyer, H ;

Boulenger, JP ;

Castelhau, D ;

Ferreira, M ;

Lambercy, C ;

Mouthon, D ;

Paoloni-Giacobino, A ;

Vessaz, M ;

Malafosse, A ;

Buresi, C .

MOLECULAR PSYCHIATRY, 2001, 6 (03) :268-273

[2] A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior [J].

Anguelova, M ;

Benkelfat, C ;

Turecki, G .

MOLECULAR PSYCHIATRY, 2003, 8 (07) :646-653

[3] The 5-HT2A receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients [J].

Arias, B ;

Gastó, C ;

Catalán, R ;

Gutiérrez, B ;

Pintor, L ;

Fañanás, L .

AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 105 (08) :801-804

[4] Neurotransmitters and suicidal behavior -: The evidence from cerebrospinal fluid studies [J].

Åsberg, M .

NEUROBIOLOGY OF SUICIDE: FROM THE BENCH TO THE CLINIC, 1997, 836 :158-181

[5] A pilot genetic study of the continuum between compulsivity and impulsivity in females:: The serotonin transporter promoter polymorphism [J].

Baca-García, E ;

Salgado, BR ;

Segal, HD ;

Lorenzo, CV ;

Acosta, MN ;

Romero, MA ;

Hernández, MD ;

Saiz-Ruiz, J ;

Piqueras, JF ;

de Leon, J .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2005, 29 (05) :713-717

[6] Lack of association between polymorphic variations in the α3 subunit GABA receptor gene (GABRA3) and suicide attempts [J].

Baca-Garcia, E ;

Vaquero, C ;

Diaz-Sastre, C ;

Jimenez-Treviño, L ;

Saiz-Ruiz, J ;

Fernández-Piqueras, J ;

de Leon, J .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2004, 28 (02) :409-412

[7] A gender-specific association between the serotonin transporter gene and suicide attempts [J].

Baca-García, E ;

Vaquero, C ;

Diaz-Sastre, C ;

Saiz-Ruiz, J ;

Fernández-Piqueras, J ;

de Leon, J .

NEUROPSYCHOPHARMACOLOGY, 2002, 26 (05) :692-695

[8] Genetics of suicide: An overview [J].

Baldessarini, RJ ;

Hennen, J .

HARVARD REVIEW OF PSYCHIATRY, 2004, 12 (01) :1-13

[9] Long-term effects of infant rearing condition on the acquisition of dominance rank in juvenile and adult rhesus macaques (Macaca mulatta) [J].

Bastian, ML ;

Sponberg, AC ;

Suomi, SJ ;

Higley, JD .

DEVELOPMENTAL PSYCHOBIOLOGY, 2003, 42 (01) :44-51

[10] SUICIDE AS ESCAPE FROM SELF [J].

BAUMEISTER, RF .

PSYCHOLOGICAL REVIEW, 1990, 97 (01) :90-113

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