In situ forming polysaccharide-based 3D-hydrogels for cell delivery in regenerative medicine

被引：41

作者：

Delair, Thierry ^{[1
]}

机构：

[1] Univ Lyon 1, Lab Ingn Mat Polymeres, F-69622 Villeurbanne, France

来源：

CARBOHYDRATE POLYMERS | 2012年 / 87卷 / 02期

关键词：

Hydrogels; Polysaccharides; In situ forming; Cell delivery; Regenerative medicine; MESENCHYMAL STEM-CELLS; ACID-BASED HYDROGELS; THERMOSENSITIVE HYDROGEL; HYALURONIC-ACID; DRUG-DELIVERY; BIODEGRADABLE HYDROGEL; VIVO BIOCOMPATIBILITY; INJECTABLE HYDROGELS; AQUEOUS-SOLUTION; GROWTH-FACTOR;

D O I：

10.1016/j.carbpol.2011.09.069

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Regenerative medicine is evolving fast, in particular since the potential of stem cells has been assessed. This evolution process requires the development of new tools capable of meeting the needs of this field of investigation. Cell delivery is a crucial issue for the success of regenerative medicine as cells should be easily seeded, expanded and introduced on site with maintenance of their phenotype and their capability to develop into a neo tissue/organ. On a material standpoint, cell delivery system should meet the preceding needs but also permit an easy introduction at the site and remain without hampering tissue development. As is shown in this review, polysaccharide hydrogels, and in particular in situ forming ones, are materials with a high application potential in regenerative medicine. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1013 / 1019

页数：7

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