Heparin-Binding Epidermal Growth Factor (HB-EGF): Myth or reality?

被引：0

作者：

Scuderi, R. ^{[1
]}

Failla, A. ^{[1
]}

机构：

[1] Policlin Univ Catania, UO Med Interna A Francaviglia, Dipartimento Med Interna & Patol Sistemiche, Catania, Italy

来源：

CLINICA TERAPEUTICA | 2008年 / 159卷 / 02期

关键词：

atherosclerosis; Diphteria Toxin; EGFR (epidermal growth factor receptor); HB-EGF (heparin-binding epidermal growth factor); oncogenesis;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin-Binding Epidermal Growth Factor (HB-EGF) is growth factor member of EGF family that stimulate differentation and growth. HB-EGF was initially identified as a secreted product of human macrophage-like cells, it is sinthetized as a transmembrana protein; proHB-EGF; that is shed by specific metalloproteases, releasing soluble growth factor(sHB-EGF). It exerts biological activity trough activation of the EGFR. sHB-EGF is implicated in diverse biological processes: angiogenesis, shin wound, blastocysts implantation, atherosclerosis, tumor formation moreover it acts as the Diphteria Toxin (DT) receptor. HB-EGF It's an important molecule because could be a novel targeting for cancer and atherosclerosis therapy.

引用

页码：111 / 116

页数：6

共 36 条

[1] ISOLATION AND CHARACTERIZATION OF A MACROPHAGE-DERIVED HEPARIN-BINDING GROWTH-FACTOR [J].