Cardiac Complications After SARS-CoV-2 Infection and mRNA COVID-19 Vaccination - PCORnet, United States, January 2021-January 2022

被引：104

作者：

Block, Jason P. ^{[1
]}

Bochmer, Tegan K. ^{[2
]}

Forrest, Christopher B. ^{[3
]}

Carton, Thomas W. ^{[4
]}

Lee, Grace M. ^{[5
]}

Ajani, Umed A. ^{[2
]}

Christakis, Dimitri A. ^{[6
]}

Cowell, Lindsay G. ^{[7
,8
]}

Draper, Christine ^{[1
]}

Ghildayal, Nidhi ^{[1
]}

Harris, Aaron M. ^{[2
]}

Kappelman, Michael D. ^{[9
]}

Ko, Jean Y. ^{[2
]}

Mayer, Kenneth H. ^{[10
]}

Nagavedu, Kshema ^{[1
]}

Oster, Matthew E. ^{[2
,11
]}

Paranjape, Anuradha ^{[12
]}

Puro, Jon ^{[13
]}

Ritchey, Matthew D. ^{[2
]}

Shay, David K. ^{[2
]}

Thacker, Deepika ^{[14
]}

Gundlapalli, Adi, V ^{[2
]}

机构：

[1] Harvard Med Sch, Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA 02115 USA

[2] CDC, COVID 19 Emergency Response Team, Atlanta, GA 30333 USA

[3] Childrens Hosp Philadelphia, Dept Pediat, Appl Clin Res Ctr, Philadelphia, PA 19104 USA

[4] Louisiana Publ Hlth Inst, New Orleans, LA USA

[5] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA

[6] Seattle Childrens Hosp, Seattle Childrens Res Inst, Ctr Child Hlth Behav & Dev, Seattle, WA USA

[7] Univ Texas Southwestern Med Ctr Dallas, Dept Populat & Data Sci, Dallas, TX 75390 USA

[8] Univ Texas Southwestern Med Ctr Dallas, Dept Immunol, Dallas, TX 75390 USA

[9] Univ N Carolina, Sch Med, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27515 USA

[10] Harvard Med Sch, Fenway Inst, Fenway Hlth, Boston, MA 02115 USA

[11] Emory Univ, Sch Med, Childrens Healthcare Atlanta, Atlanta, GA USA

[12] Temple Univ, Lewis Katz Sch Med, Dept Med, Philadelphia, PA 19122 USA

[13] OCHIN Inc, Portland, OR USA

[14] Nemours Childrens Hlth Syst, Nemours Cardiac Ctr, Wilmington, DE USA

来源：

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT | 2022年 / 71卷 / 14期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.15585/mmwr.mm7114e1

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Cardiac complications, particularly myocarditis and pericarditis, have been associated with SARS-CoV-2 (the virus that causes COVID-19) infection (1-3) and mRNA COVID-19 vaccination (2-5). Multisystem inflammatory syndrome (MIS) is a rare but serious complication of SARS-CoV-2 infection with frequent cardiac involvement (6). Using electronic health record (EHR) data from 40 U.S. health care systems during January 1, 2021-January 31, 2022, investigators calculated incidences of cardiac outcomes (myocarditis; myocarditis or pericarditis; and myocarditis, pericarditis, or MIS) among persons aged >= 5 years who had SARS-CoV-2 infection, stratified by sex (male or female) and age group (5-11, 12-17, 18-29, and >= 30 years). Incidences of myocarditis and myocarditis or pericarditis were calculated after first, second, unspecified, or any (first, second, or unspecified) dose of mRNA COVID-19 (BNT162b2 [Pfizer-BioNTech] or mRNA-1273 [Moderna]) vaccines, stratified by sex and age group. Risk ratios (RR) were calculated to compare risk for cardiac outcomes after SARS-CoV-2 infection to that after mRNA COVID-19 vaccination. The incidence of cardiac outcomes after mRNA COVID-19 vaccination was highest for males aged 12-17 years after the second vaccine dose; however, within this demographic group, the risk for cardiac outcomes was 1.8-5.6 times as high after SARS-CoV-2 infection than after the second vaccine dose. The risk for cardiac outcomes was likewise significantly higher after SARS-CoV-2 infection than after first, second, or unspecified dose of mRNA COVID-19 vaccination for all other groups by sex and age (RR 2.2-115.2). These findings support continued use of mRNA COVID-19 vaccines among all eligible persons aged >= 5 years.

引用

页码：517 / 523

页数：7

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