RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder

被引：13

作者：

Huuhka, Kaija ^{[1
,2
]}

Kampman, Olli ^{[1
,3
]}

Anttila, Sami ^{[1
,4
]}

Huuhka, Martti ^{[1
,2
]}

Rontu, Riikka ^{[1
,4
]}

Mattila, Kari M. ^{[1
,4
]}

Hurme, Mikko ^{[1
,4
]}

Lehtimaki, Terho ^{[1
,4
]}

Leinonen, Esa ^{[1
,2
]}

机构：

[1] Univ Tampere, Sch Med, Tampere 33014, Finland

[2] Tampere Univ Hosp, Dept Psychiat, Pitkaniemi 33380, Finland

[3] Seinajoki Hosp Dist, Dept Psychiat, Seinajoki, Finland

[4] Tampere Univ Hosp, Dept Clin Chem, Lab Atherosclerosis Genet, Ctr Lab Med, FIN-33521 Tampere, Finland

来源：

NEUROSCIENCE LETTERS | 2008年 / 437卷 / 01期

关键词：

RGS4; major depression; electroconvulsive therapy;

D O I：

10.1016/j.neulet.2008.03.065

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the association between RGS4 (rs951436) polymorphism and treatment response in electroconvulsive therapy (ECT) as well as risk of treatment-resistant depression. The study sample consisted of 119 patients with major depressive disorder (MDD) and 384 healthy control subjects. RGS4 polymorphism was not associated with treatment response in ECT or risk of MDD. According to the present data, the impact of RGS4 genotype is not decisive in major depressive disorder. The results provide preliminary data on the impact of RGS4 polymorphism in treatment response in ECT. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：25 / 28

页数：4

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