共 48 条
Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies
被引:87
作者:

Mamonkin, Maksim
论文数: 0 引用数: 0
h-index: 0
机构:
Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Mukherjee, Malini
论文数: 0 引用数: 0
h-index: 0
机构:
Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
Texas Childrens Hosp, Ctr Human Immunobiol, Houston, TX 77030 USA Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Srinivasan, Madhuwanti
论文数: 0 引用数: 0
h-index: 0
机构:
Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Sharma, Sandhya
论文数: 0 引用数: 0
h-index: 0
机构:
Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
Baylor Coll Med, Interdept Grad Program Translat Biol & Mol Med, Houston, TX 77030 USA Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Gomes-Silva, Diogo
论文数: 0 引用数: 0
h-index: 0
机构:
Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
Univ Lisbon, Inst Super Tecn, Lisbon, Portugal Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Mo, Feiyan
论文数: 0 引用数: 0
h-index: 0
机构:
Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
Baylor Coll Med, Interdept Grad Program Translat Biol & Mol Med, Houston, TX 77030 USA Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Krenciute, Giedre
论文数: 0 引用数: 0
h-index: 0
机构:
Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Orange, Jordan S.
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
Texas Childrens Hosp, Ctr Human Immunobiol, Houston, TX 77030 USA
Baylor Coll Med, Interdept Grad Program Translat Biol & Mol Med, Houston, TX 77030 USA Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Brenner, Malcolm K.
论文数: 0 引用数: 0
h-index: 0
机构:
Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
Baylor Coll Med, Interdept Grad Program Translat Biol & Mol Med, Houston, TX 77030 USA Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
机构:
[1] Texas Childrens Hosp, Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
[4] Texas Childrens Hosp, Ctr Human Immunobiol, Houston, TX 77030 USA
[5] Baylor Coll Med, Interdept Grad Program Translat Biol & Mol Med, Houston, TX 77030 USA
[6] Univ Lisbon, Inst Super Tecn, Lisbon, Portugal
关键词:
CHIMERIC ANTIGEN RECEPTOR;
INTERCELLULAR-ADHESION MOLECULE-1;
NATURAL-KILLER-CELLS;
KAPPA-B;
IMMUNOLOGICAL SYNAPSE;
ANTITUMOR-ACTIVITY;
EFFECTOR FUNCTION;
INTERFERON-GAMMA;
IN-VIVO;
ACTIVATION;
D O I:
10.1158/2326-6066.CIR-17-0126
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
T cells expressing second-generation chimeric antigen receptors (CARs) specific for CD5, a T-cell surface marker present on normal and malignant T cells, can selectively kill tumor cells. We aimed to improve this killing by substituting the CD28 costimulatory endodomain (28. z) with 4-1BB (BB. z), as 28. z CD5 CAR T cells rapidly differentiated into short-lived effector cells. In contrast, 4-1BB costimulation is known to promote development of the central memory subpopulation. Here, we found BB. z CD5 CAR T cells had impaired growth compared with 28. z CD5. CAR T cells, due to increased T-cell-T-cell fratricide. We demonstrate that TRAF signaling from the 4-1BB endodomain upregulated the intercellular adhesion molecule 1, which stabilized the fratricidal immunologic synapse between CD5 CAR T cells. As the surviving BB. z CD5 CAR T cells retained the desired central memory phenotype, we aimed to circumvent the 4-1BB-mediated toxicity using a regulated expression system that reversibly inhibits CAR expression. This system minimized CAR signaling and T-cell fratricide during in vitro expansion in the presence of a small-molecule inhibitor, and restored CAR expression and antitumor function of transduced T cells in vivo. These studies reveal a mechanism by which 4-1BB costimulation impairs expansion of CD5 CAR T cells and offer a solution to mitigate this toxicity. (C) 2017 AACR.
引用
收藏
页码:47 / 58
页数:12
相关论文
共 48 条
[1]
Quantitative measurement of F-actin accumulation at the NK cell immunological synapse
[J].
Banerjee, Pinaki P.
;
Orange, Jordan S.
.
JOURNAL OF IMMUNOLOGICAL METHODS,
2010, 355 (1-2)
:1-13

Banerjee, Pinaki P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Immunol,Res Inst, Philadelphia, PA 19104 USA Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Immunol,Res Inst, Philadelphia, PA 19104 USA

Orange, Jordan S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Immunol,Res Inst, Philadelphia, PA 19104 USA Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Immunol,Res Inst, Philadelphia, PA 19104 USA
[2]
Regulation of T-cell activation by the cytoskeleton
[J].
Billadeau, Daniel D.
;
Nolz, Jeffrey C.
;
Gomez, Timothy S.
.
NATURE REVIEWS IMMUNOLOGY,
2007, 7 (02)
:131-143

Billadeau, Daniel D.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Nolz, Jeffrey C.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Gomez, Timothy S.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55905 USA
[3]
An Enigmatic Tail of CD28 Signaling
[J].
Boomer, Jonathan S.
;
Green, Jonathan M.
.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY,
2010, 2 (08)
:a002436

Boomer, Jonathan S.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA

Green, Jonathan M.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
[4]
CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia
[J].
Brentjens, Renier J.
;
Davila, Marco L.
;
Riviere, Isabelle
;
Park, Jae
;
Wang, Xiuyan
;
Cowell, Lindsay G.
;
Bartido, Shirley
;
Stefanski, Jolanta
;
Taylor, Clare
;
Olszewska, Malgorzata
;
Borquez-Ojeda, Oriana
;
Qu, Jinrong
;
Wasielewska, Teresa
;
He, Qing
;
Bernal, Yvette
;
Rijo, Ivelise V.
;
Hedvat, Cyrus
;
Kobos, Rachel
;
Curran, Kevin
;
Steinherz, Peter
;
Jurcic, Joseph
;
Rosenblat, Todd
;
Maslak, Peter
;
Frattini, Mark
;
Sadelain, Michel
.
SCIENCE TRANSLATIONAL MEDICINE,
2013, 5 (177)

Brentjens, Renier J.
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Davila, Marco L.
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Riviere, Isabelle
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Park, Jae
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Wang, Xiuyan
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Cowell, Lindsay G.
论文数: 0 引用数: 0
h-index: 0
机构:
UT Southwestern, Dept Clin Sci, Dallas, TX 75390 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Bartido, Shirley
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Stefanski, Jolanta
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Taylor, Clare
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Olszewska, Malgorzata
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Borquez-Ojeda, Oriana
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Qu, Jinrong
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Wasielewska, Teresa
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

He, Qing
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Cell Therapy & Cell Engn Facil, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Bernal, Yvette
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Rijo, Ivelise V.
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Hedvat, Cyrus
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Kobos, Rachel
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Curran, Kevin
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Steinherz, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Jurcic, Joseph
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Rosenblat, Todd
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Maslak, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Frattini, Mark
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

Sadelain, Michel
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, New York, NY 10065 USA Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
[5]
HUMAN-MEMORY T-CELLS EXPRESS INTERCELLULAR-ADHESION MOLECULE-1 WHICH CAN BE INCREASED BY INTERLEUKIN-2 AND INTERFERON-GAMMA
[J].
BUCKLE, AM
;
HOGG, N
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
1990, 20 (02)
:337-341

BUCKLE, AM
论文数: 0 引用数: 0
h-index: 0
机构: Macrophage Laboratory, Imperial Cancer Research Fund, London, Lincoln's Inn Fields

HOGG, N
论文数: 0 引用数: 0
h-index: 0
机构: Macrophage Laboratory, Imperial Cancer Research Fund, London, Lincoln's Inn Fields
[6]
A key role for ICAM-I in generating effector cells mediating inflammatory responses
[J].
Camacho, SA
;
Heath, WR
;
Carbone, FR
;
Sarvetnick, N
;
LeBon, A
;
Karlsson, L
;
Peterson, PA
;
Webb, SR
.
NATURE IMMUNOLOGY,
2001, 2 (06)
:523-529

Camacho, SA
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

Heath, WR
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

Carbone, FR
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

Sarvetnick, N
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

LeBon, A
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

Karlsson, L
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

Peterson, PA
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

Webb, SR
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
[7]
Molecular mechanisms of T cell co-stimulation and co-inhibition
[J].
Chen, Lieping
;
Flies, Dallas B.
.
NATURE REVIEWS IMMUNOLOGY,
2013, 13 (04)
:227-242

Chen, Lieping
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06519 USA
Yale Univ, Sch Med, Yale Canc Ctr, New Haven, CT 06519 USA Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06519 USA

Flies, Dallas B.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06519 USA
Yale Univ, Sch Med, Yale Canc Ctr, New Haven, CT 06519 USA Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06519 USA
[8]
Regulation and function of mTOR signalling in T cell fate decisions
[J].
Chi, Hongbo
.
NATURE REVIEWS IMMUNOLOGY,
2012, 12 (05)
:325-338

Chi, Hongbo
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
[9]
CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma
[J].
Chu, J.
;
Deng, Y.
;
Benson, D. M.
;
He, S.
;
Hughes, T.
;
Zhang, J.
;
Peng, Y.
;
Mao, H.
;
Yi, L.
;
Ghoshal, K.
;
He, X.
;
Devine, S. M.
;
Zhang, X.
;
Caligiuri, M. A.
;
Hofmeister, C. C.
;
Yu, J.
.
LEUKEMIA,
2014, 28 (04)
:917-927

Chu, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Deng, Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
Third Mil Med Univ, Coll Pharm, Inst Mat Med, Chongqing, Peoples R China Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Benson, D. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

He, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Hughes, T.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Zhang, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Biostat, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Peng, Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Mao, H.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Yi, L.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Ghoshal, K.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

He, X.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Devine, S. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
Ohio State Univ, James Canc Hosp, Blood & Marrow Transplantat Program, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Zhang, X.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Houston, Ctr Nucl Receptors & Cell Signaling, Sci & Engn Res Ctr 3005, Dept Biol & Biochem, Houston, TX USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Caligiuri, M. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Hofmeister, C. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

Yu, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
Ohio State Univ, James Canc Hosp, Blood & Marrow Transplantat Program, Columbus, OH 43210 USA Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
[10]
ICAM-1-dependent tuning of memory CD8 T-cell responses following acute infection
[J].
Cox, Maureen A.
;
Barnum, Scott R.
;
Bullard, Daniel C.
;
Zajac, Allan J.
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2013, 110 (04)
:1416-1421

Cox, Maureen A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

Barnum, Scott R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

Bullard, Daniel C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Genet, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

Zajac, Allan J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA