Tetrahedral Framework Nucleic Acids Can Alleviate Taurocholate-Induced Severe Acute Pancreatitis and Its Subsequent Multiorgan Injury in Mice

被引：95
作者：
Wang, Yun [1 ]
Li, Yanjing [1 ]
Gao, Shaojingya [1 ]
Yu, Xi [2 ,3 ]
Chen, Yu [1 ]
Lin, Yunfeng [1 ,4 ]
机构：
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Orthoped Surg, Med Ctr, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp, Res Inst Rehabil, Med Ctr, Chengdu 610041, Sichuan, Peoples R China
[4] Sichuan Univ, Coll Biomed Engn, Chengdu 610041, Sichuan, Peoples R China
来源：
NANO LETTERS | 2022年 / 22卷 / 04期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Severe acute pancreatitis; Tetrahedral framework nucleic acids; Multiorgan injury; Apoptosis; Inflammation; INFLAMMATORY RESPONSE; DNA NANOSTRUCTURES; ACTIVATION; MARKERS; CELLS;
D O I：
10.1021/acs.nanolett.1c05003
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Severe acute pancreatitis (SAP) is an inflammatory disease of the pancreas accompanied by tissue injury and necrosis. It not only affects the pancreas but also triggers a systemic inflammatory response that leads to multiorgan failure or even death. Moreover, there is no effective treatment currently that can reverse the disease progression. In this study, tetrahedral framework nucleic acids (tFNAs) were utilized to treat SAP in mice for the first time and proved to be effective in suppressing inflammation and preventing pathological cell death. Serum levels of pancreatitis-related biomarkers witnessed significant changes after tFNAs treatment. Reduction in the expression of certain cytokines involved in local and systemic inflammatory response were observed, together with alteration in proteins related to cell death and apoptosis. Collectively, our results demonstrate that tFNAs could both alleviate SAP and its subsequent multiorgan injury in mice, thus offering a novel and effective option to deal with SAP in the future.
引用
收藏
页码：1759 / 1768
页数：10
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