Evaluation of Strychnos pseudoquina ST. HIL. leaves extract on gastrointestinal activity in mice

被引：21
作者：
da Silva, MA
Rafacho, BPM
Hiruma-Lima, CA
da Rocha, LRM
dos Santos, LC
Sannomiya, M
Souza-Brito, ARM
Vilegas, W
机构：
[1] UNESP, Dept Quim Organ, Inst Quim, BR-14800900 Araraquara, SP, Brazil
[2] UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, BR-14800900 Araraquara, SP, Brazil
[3] Univ Estadual Paulista Julio Mesquita Filho, Dept Fisiol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
[4] UNICAMP, Dept Fisiol & Biofis, Inst Biol, BR-13083970 Campinas, SP, Brazil
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 08期
关键词：
Strychnos pseudoquina; antiulcer activity; toxic activity; alkaloid;
D O I：
10.1248/cpb.53.881
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Strychnos pseudoquina Sr. HiL.. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects.
引用
收藏
页码：881 / 885
页数：5
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